| pubmed-article:3717330 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3717330 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:3717330 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:3717330 | lifeskim:mentions | umls-concept:C1705480 | lld:lifeskim |
| pubmed-article:3717330 | lifeskim:mentions | umls-concept:C0006100 | lld:lifeskim |
| pubmed-article:3717330 | lifeskim:mentions | umls-concept:C0596019 | lld:lifeskim |
| pubmed-article:3717330 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:3717330 | pubmed:issue | 6 Pt 1 | lld:pubmed |
| pubmed-article:3717330 | pubmed:dateCreated | 1986-7-23 | lld:pubmed |
| pubmed-article:3717330 | pubmed:abstractText | We have characterized a Na+-K+-Cl- cotransporter in vascular endothelial cells (EC) cultured from different blood vessels and species that is inhibited by the diuretics furosemide and bumetanide (50% inhibitory concentration for 86Rb influx approximately 20 microM and 0.5 microM, respectively). Inward 86Rb influx mediated via this pathway is greater than 86Rb influx transported by the Na+-K+ pump in cultured EC from bovine and pig aorta, bovine vena cava, and baboon cephalic vein but not in human umbilical or saphenous vein EC. External Na+ or Cl- -stimulated, ouabain-insensitive 86Rb influx is equal to furosemide or bumetanide-sensitive 86Rb influx. Ouabain-insensitive 22Na influx is also partially inhibited by these drugs and stimulated by increasing external K+ or Cl-. Net Na+ extrusion occurs via the Na+-K+-Cl- cotransporter in the absence of external K+, whereas net Na+ influx occurs at higher external K+ (greater than 1 mM). Maximal concentrations (100 nM) of bradykinin and vasopressin increase the initial rate of bumetanide-sensitive 86Rb influx by approximately 60 and 70% (50% effective concentration approximately 1 and 0.6 nM, respectively). Addition of either ethyleneglycol-bis(beta-aminotethylether)-N,N'-tetraacetic acid or LaCl3 (to block calcium influx) prevents bradykinin-stimulated 86Rb influx. When intracellular calcium is elevated using ionomycin (100 nM), a Ca2+ ionophore, bumetanide-sensitive 86Rb influx increases approximately twofold. In contrast, isoproterenol (100 microM) and forskolin (50 microM), adenylate cyclase stimulators, decrease furosemide-sensitive 86Rb influx.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
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| pubmed-article:3717330 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3717330 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3717330 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3717330 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3717330 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:3717330 | pubmed:author | pubmed-author:CanessaMM | lld:pubmed |
| pubmed-article:3717330 | pubmed:author | pubmed-author:GimbroneM... | lld:pubmed |
| pubmed-article:3717330 | pubmed:author | pubmed-author:BrockT ATA | lld:pubmed |
| pubmed-article:3717330 | pubmed:author | pubmed-author:BrugnaraCC | lld:pubmed |
| pubmed-article:3717330 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3717330 | pubmed:volume | 250 | lld:pubmed |
| pubmed-article:3717330 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3717330 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3717330 | pubmed:pagination | C888-95 | lld:pubmed |
| pubmed-article:3717330 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:3717330 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3717330 | pubmed:articleTitle | Bradykinin and vasopressin stimulate Na+-K+-Cl- cotransport in cultured endothelial cells. | lld:pubmed |
| pubmed-article:3717330 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3717330 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3717330 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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