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pubmed-article:3692487pubmed:abstractTextWith the advent of RFLPs, genetic linkage maps are now being assembled for a number of organisms including both inbred experimental populations such as maize and outbred natural populations such as humans. Accurate construction of such genetic maps requires multipoint linkage analysis of particular types of pedigrees. We describe here a computer package, called MAPMAKER, designed specifically for this purpose. The program uses an efficient algorithm that allows simultaneous multipoint analysis of any number of loci. MAPMAKER also includes an interactive command language that makes it easy for a geneticist to explore linkage data. MAPMAKER has been applied to the construction of linkage maps in a number of organisms, including the human and several plants, and we outline the mapping strategies that have been used.lld:pubmed
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pubmed-article:3692487pubmed:authorpubmed-author:GaleA MAMlld:pubmed
pubmed-article:3692487pubmed:authorpubmed-author:GreenPPlld:pubmed
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pubmed-article:3692487pubmed:authorpubmed-author:NewbergL ALAlld:pubmed
pubmed-article:3692487pubmed:authorpubmed-author:LanderE SESlld:pubmed
pubmed-article:3692487pubmed:authorpubmed-author:LincolnS ESElld:pubmed
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pubmed-article:3692487pubmed:pagination174-81lld:pubmed
pubmed-article:3692487pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:3692487pubmed:articleTitleMAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations.lld:pubmed
pubmed-article:3692487pubmed:affiliationWhitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.lld:pubmed
pubmed-article:3692487pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3692487pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
pubmed-article:3692487pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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