| pubmed-article:3689319 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3689319 | lifeskim:mentions | umls-concept:C0007635 | lld:lifeskim |
| pubmed-article:3689319 | lifeskim:mentions | umls-concept:C0063164 | lld:lifeskim |
| pubmed-article:3689319 | lifeskim:mentions | umls-concept:C0041536 | lld:lifeskim |
| pubmed-article:3689319 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:3689319 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:3689319 | lifeskim:mentions | umls-concept:C1553423 | lld:lifeskim |
| pubmed-article:3689319 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3689319 | pubmed:dateCreated | 1987-12-29 | lld:pubmed |
| pubmed-article:3689319 | pubmed:abstractText | The cellular content of ubiquinone was increased approx. 10-fold by incubation of neuroblastoma cells in medium containing exogenous ubiquinone. Under these conditions the activity of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, assayed after preincubation of cell homogenates with or without fluoride, was not suppressed. Similar results were obtained with human skin fibroblast cultures to which free ubiquinone or low-density lipoprotein-ubiquinone complex had been added. Consistent with the lack of suppression of HMG-CoA reductase, the rate of incorporation of [1-14C] acetate into ubiquinone was not diminished in cells exposed to exogenous ubiquinone. Measurements of [3H]mevalonolactone incorporation into cellular ubiquinones indicated that exogenous ubiquinone did not affect ubiquinone synthesis at a point in the pathway distal to the formation of mevalonate. The results suggest that cultured mammalian cells lack an end-product 'feedback' mechanism for regulation of HMG-CoA reductase in response to ubiquinone uptake. | lld:pubmed |
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| pubmed-article:3689319 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3689319 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3689319 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3689319 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3689319 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3689319 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:3689319 | pubmed:author | pubmed-author:GreenR ARA | lld:pubmed |
| pubmed-article:3689319 | pubmed:author | pubmed-author:AprilleJ RJR | lld:pubmed |
| pubmed-article:3689319 | pubmed:author | pubmed-author:MalteseW AWA | lld:pubmed |
| pubmed-article:3689319 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3689319 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:3689319 | pubmed:volume | 246 | lld:pubmed |
| pubmed-article:3689319 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3689319 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3689319 | pubmed:pagination | 441-7 | lld:pubmed |
| pubmed-article:3689319 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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