| pubmed-article:3675692 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3675692 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3675692 | lifeskim:mentions | umls-concept:C0001563 | lld:lifeskim |
| pubmed-article:3675692 | lifeskim:mentions | umls-concept:C0042523 | lld:lifeskim |
| pubmed-article:3675692 | lifeskim:mentions | umls-concept:C0683150 | lld:lifeskim |
| pubmed-article:3675692 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:3675692 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
| pubmed-article:3675692 | lifeskim:mentions | umls-concept:C0069036 | lld:lifeskim |
| pubmed-article:3675692 | lifeskim:mentions | umls-concept:C0520510 | lld:lifeskim |
| pubmed-article:3675692 | lifeskim:mentions | umls-concept:C0524527 | lld:lifeskim |
| pubmed-article:3675692 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:3675692 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:3675692 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:3675692 | pubmed:dateCreated | 1987-12-16 | lld:pubmed |
| pubmed-article:3675692 | pubmed:abstractText | A method for the simultaneous determination of the cardiovascular agent verapamil and its major metabolite norverapamil in human plasma is described. Analysis is performed after alkaline extraction with n-heptane by subsequent ion-paired high performance liquid chromatographic (HPLC) separation, and direct fluorimetric measurement of both compounds (lambda maxex. = 278 nm, lambda maxem. = 320 nm). The sensitivity of the procedure (detection limit less than 1 ng/ml) is suitable for pharmacokinetic studies after therapeutic doses. The applicability of the method was tested by performing a clinical study. Plasma concentrations of two verapamil formulations for oral administration were examined. The active metabolite norverapamil was included in the investigation. | lld:pubmed |
| pubmed-article:3675692 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3675692 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3675692 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3675692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3675692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3675692 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3675692 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3675692 | pubmed:issn | 0004-4172 | lld:pubmed |
| pubmed-article:3675692 | pubmed:author | pubmed-author:KnaufHH | lld:pubmed |
| pubmed-article:3675692 | pubmed:author | pubmed-author:MutschlerEE | lld:pubmed |
| pubmed-article:3675692 | pubmed:author | pubmed-author:HorneCC | lld:pubmed |
| pubmed-article:3675692 | pubmed:author | pubmed-author:SpahnHH | lld:pubmed |
| pubmed-article:3675692 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3675692 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:3675692 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3675692 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3675692 | pubmed:pagination | 956-9 | lld:pubmed |
| pubmed-article:3675692 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3675692 | pubmed:meshHeading | pubmed-meshheading:3675692-... | lld:pubmed |
| pubmed-article:3675692 | pubmed:meshHeading | pubmed-meshheading:3675692-... | lld:pubmed |
| pubmed-article:3675692 | pubmed:meshHeading | pubmed-meshheading:3675692-... | lld:pubmed |
| pubmed-article:3675692 | pubmed:meshHeading | pubmed-meshheading:3675692-... | lld:pubmed |
| pubmed-article:3675692 | pubmed:meshHeading | pubmed-meshheading:3675692-... | lld:pubmed |
| pubmed-article:3675692 | pubmed:meshHeading | pubmed-meshheading:3675692-... | lld:pubmed |
| pubmed-article:3675692 | pubmed:meshHeading | pubmed-meshheading:3675692-... | lld:pubmed |
| pubmed-article:3675692 | pubmed:meshHeading | pubmed-meshheading:3675692-... | lld:pubmed |
| pubmed-article:3675692 | pubmed:meshHeading | pubmed-meshheading:3675692-... | lld:pubmed |
| pubmed-article:3675692 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3675692 | pubmed:articleTitle | Determination of verapamil and norverapamil in human biological material. Investigation of plasma concentrations after oral administration of two different verapamil formulations. | lld:pubmed |
| pubmed-article:3675692 | pubmed:affiliation | Pharmakologisches Institut für Naturwissenschaftler der Johann Wolfgang Goethe-Universität, Frankfurt/Main, Fed. Rep. of Germany. | lld:pubmed |
| pubmed-article:3675692 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3675692 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3675692 | lld:pubmed |
