pubmed-article:3656149 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3656149 | lifeskim:mentions | umls-concept:C0043047 | lld:lifeskim |
pubmed-article:3656149 | lifeskim:mentions | umls-concept:C1882727 | lld:lifeskim |
pubmed-article:3656149 | lifeskim:mentions | umls-concept:C0000854 | lld:lifeskim |
pubmed-article:3656149 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
pubmed-article:3656149 | lifeskim:mentions | umls-concept:C0969655 | lld:lifeskim |
pubmed-article:3656149 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
pubmed-article:3656149 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
pubmed-article:3656149 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
pubmed-article:3656149 | pubmed:dateCreated | 1987-11-16 | lld:pubmed |
pubmed-article:3656149 | pubmed:abstractText | 1. Experiments were performed on isolated rat lungs perfused with Ringer solutions containing red cells. The goal was to clarify the role of active transport of Na+ for the absorption of fluid across the alveolar membrane, and to characterize active and passive pathways. 2. Partially degassed lungs were filled with 5 ml of an isotonic Ringer solution containing 125I-labelled albumin in order to calculate the fluid movement, and 22Na+ or 36Cl- for measurement of ion fluxes. Passive non-electrolyte permeability was determined in all experiments using [3H]mannitol. 3. The average rate of fluid absorption in phosphate-buffered instillates was 134 nl/s (S.E., 18.5; n = 14). With ouabain (10(-4) M) in the perfusate the fluid absorption rate fell to 57 nl/s (S.E., 8.2; n = 18). Amiloride (10(-3)-10(-4) M) in the instillate reduced the absorption to 75 nl/s (S.E., 8.6; n = 16). These results show that fluid absorption depends on transcellular transport of Na+ and that alveolar epithelial cells have a Na+ entry system in the luminal membrane and a Na+-K+ pump in the abluminal membrane. 4. The transcellular ion transport operates in parallel with a paracellular, passive leak that allows mannitol to pass with a permeability surface area product of 1.2 X 10(-4) ml/s, corresponding to a permeability coefficient of 2.4 X 10(-8) cm/s, assuming an alveolar surface area of 5000 cm2. 5. The passive fluxes of Na+ were 9.4 pmol/(cm2s) (S.E., 1.3; n = 25) in the direction from alveoli to perfusate and 8.0 pmol/(cm2s) (S.E., 0.86; n = 6) from perfusate to plasma. The passive fluxes of Cl- in the two directions were not significantly different either. Thus the transalveolar electrical potential difference is too small to affect ion movements measurably. 6. The passive permeability to Na+ was 6.7 X 10(-8) cm/s and to Cl- was 10.2 X 10(-8) cm/s (alveolar surface area assumed to be 5000 cm2). The ratio of the permeabilities is close to the ratio of the diffusion coefficients in free solution, suggesting a neutral or weakly charged paracellular channel. 7. We conclude that the alveolar epithelium performs solute-coupled fluid transport from alveoli to plasma, and that it shows many features that are common to other fluid-transporting epithelia; with an approximate surface area of 100 m2 in humans it constitutes one of the largest epithelial surfaces in the body.(ABSTRACT TRUNCATED AT 400 WORDS) | lld:pubmed |
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pubmed-article:3656149 | pubmed:language | eng | lld:pubmed |
pubmed-article:3656149 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3656149 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:3656149 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3656149 | pubmed:month | Mar | lld:pubmed |
pubmed-article:3656149 | pubmed:issn | 0022-3751 | lld:pubmed |
pubmed-article:3656149 | pubmed:author | pubmed-author:BassetGG | lld:pubmed |
pubmed-article:3656149 | pubmed:author | pubmed-author:CroneCC | lld:pubmed |
pubmed-article:3656149 | pubmed:author | pubmed-author:SaumonGG | lld:pubmed |
pubmed-article:3656149 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3656149 | pubmed:volume | 384 | lld:pubmed |
pubmed-article:3656149 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3656149 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3656149 | pubmed:pagination | 311-24 | lld:pubmed |
pubmed-article:3656149 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:3656149 | pubmed:year | 1987 | lld:pubmed |
pubmed-article:3656149 | pubmed:articleTitle | Significance of active ion transport in transalveolar water absorption: a study on isolated rat lung. | lld:pubmed |
pubmed-article:3656149 | pubmed:affiliation | Département de Physiologie, Université Paris, France. | lld:pubmed |
pubmed-article:3656149 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:3656149 | pubmed:publicationType | In Vitro | lld:pubmed |
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