Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:3656149rdf:typepubmed:Citationlld:pubmed
pubmed-article:3656149lifeskim:mentionsumls-concept:C0043047lld:lifeskim
pubmed-article:3656149lifeskim:mentionsumls-concept:C1882727lld:lifeskim
pubmed-article:3656149lifeskim:mentionsumls-concept:C0000854lld:lifeskim
pubmed-article:3656149lifeskim:mentionsumls-concept:C0205409lld:lifeskim
pubmed-article:3656149lifeskim:mentionsumls-concept:C0969655lld:lifeskim
pubmed-article:3656149lifeskim:mentionsumls-concept:C0237881lld:lifeskim
pubmed-article:3656149lifeskim:mentionsumls-concept:C2603343lld:lifeskim
pubmed-article:3656149lifeskim:mentionsumls-concept:C0750502lld:lifeskim
pubmed-article:3656149pubmed:dateCreated1987-11-16lld:pubmed
pubmed-article:3656149pubmed:abstractText1. Experiments were performed on isolated rat lungs perfused with Ringer solutions containing red cells. The goal was to clarify the role of active transport of Na+ for the absorption of fluid across the alveolar membrane, and to characterize active and passive pathways. 2. Partially degassed lungs were filled with 5 ml of an isotonic Ringer solution containing 125I-labelled albumin in order to calculate the fluid movement, and 22Na+ or 36Cl- for measurement of ion fluxes. Passive non-electrolyte permeability was determined in all experiments using [3H]mannitol. 3. The average rate of fluid absorption in phosphate-buffered instillates was 134 nl/s (S.E., 18.5; n = 14). With ouabain (10(-4) M) in the perfusate the fluid absorption rate fell to 57 nl/s (S.E., 8.2; n = 18). Amiloride (10(-3)-10(-4) M) in the instillate reduced the absorption to 75 nl/s (S.E., 8.6; n = 16). These results show that fluid absorption depends on transcellular transport of Na+ and that alveolar epithelial cells have a Na+ entry system in the luminal membrane and a Na+-K+ pump in the abluminal membrane. 4. The transcellular ion transport operates in parallel with a paracellular, passive leak that allows mannitol to pass with a permeability surface area product of 1.2 X 10(-4) ml/s, corresponding to a permeability coefficient of 2.4 X 10(-8) cm/s, assuming an alveolar surface area of 5000 cm2. 5. The passive fluxes of Na+ were 9.4 pmol/(cm2s) (S.E., 1.3; n = 25) in the direction from alveoli to perfusate and 8.0 pmol/(cm2s) (S.E., 0.86; n = 6) from perfusate to plasma. The passive fluxes of Cl- in the two directions were not significantly different either. Thus the transalveolar electrical potential difference is too small to affect ion movements measurably. 6. The passive permeability to Na+ was 6.7 X 10(-8) cm/s and to Cl- was 10.2 X 10(-8) cm/s (alveolar surface area assumed to be 5000 cm2). The ratio of the permeabilities is close to the ratio of the diffusion coefficients in free solution, suggesting a neutral or weakly charged paracellular channel. 7. We conclude that the alveolar epithelium performs solute-coupled fluid transport from alveoli to plasma, and that it shows many features that are common to other fluid-transporting epithelia; with an approximate surface area of 100 m2 in humans it constitutes one of the largest epithelial surfaces in the body.(ABSTRACT TRUNCATED AT 400 WORDS)lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:languageenglld:pubmed
pubmed-article:3656149pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:citationSubsetIMlld:pubmed
pubmed-article:3656149pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3656149pubmed:statusMEDLINElld:pubmed
pubmed-article:3656149pubmed:monthMarlld:pubmed
pubmed-article:3656149pubmed:issn0022-3751lld:pubmed
pubmed-article:3656149pubmed:authorpubmed-author:BassetGGlld:pubmed
pubmed-article:3656149pubmed:authorpubmed-author:CroneCClld:pubmed
pubmed-article:3656149pubmed:authorpubmed-author:SaumonGGlld:pubmed
pubmed-article:3656149pubmed:issnTypePrintlld:pubmed
pubmed-article:3656149pubmed:volume384lld:pubmed
pubmed-article:3656149pubmed:ownerNLMlld:pubmed
pubmed-article:3656149pubmed:authorsCompleteYlld:pubmed
pubmed-article:3656149pubmed:pagination311-24lld:pubmed
pubmed-article:3656149pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:meshHeadingpubmed-meshheading:3656149-...lld:pubmed
pubmed-article:3656149pubmed:year1987lld:pubmed
pubmed-article:3656149pubmed:articleTitleSignificance of active ion transport in transalveolar water absorption: a study on isolated rat lung.lld:pubmed
pubmed-article:3656149pubmed:affiliationDépartement de Physiologie, Université Paris, France.lld:pubmed
pubmed-article:3656149pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3656149pubmed:publicationTypeIn Vitrolld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3656149lld:pubmed