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pubmed-article:3654715pubmed:abstractTextNeuropsychiatric complications are commonly seen in major burn patients. Haloperidol is frequently used to treat severe psychopathic behavior. We have noted severe muscle rigidity-an extrapyramidal side effect of the agent-in a number of burn patients. Haloperidol causes a relative imbalance of dopaminergic and cholinergic neuronal activity in the basal ganglia with a relative increase in cholinergic activity being responsible for EPS. The burn patient may be more prone to extrapyramidal symptoms because of increased sensitivity of skeletal muscle neuromuscular junctions to acetylcholine after thermal injury.lld:pubmed
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pubmed-article:3654715pubmed:articleTitleHaloperidol complications in burn patients.lld:pubmed
pubmed-article:3654715pubmed:affiliationLongwood Area Trauma and Burn Center, Harvard Medical School, Boston, MA 02115.lld:pubmed
pubmed-article:3654715pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3654715pubmed:publicationTypeCase Reportslld:pubmed