pubmed-article:3653008 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3653008 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
pubmed-article:3653008 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:3653008 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
pubmed-article:3653008 | lifeskim:mentions | umls-concept:C0017471 | lld:lifeskim |
pubmed-article:3653008 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
pubmed-article:3653008 | lifeskim:mentions | umls-concept:C0442043 | lld:lifeskim |
pubmed-article:3653008 | lifeskim:mentions | umls-concept:C0013936 | lld:lifeskim |
pubmed-article:3653008 | lifeskim:mentions | umls-concept:C0282637 | lld:lifeskim |
pubmed-article:3653008 | lifeskim:mentions | umls-concept:C0376452 | lld:lifeskim |
pubmed-article:3653008 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
pubmed-article:3653008 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
pubmed-article:3653008 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:3653008 | pubmed:dateCreated | 1987-11-19 | lld:pubmed |
pubmed-article:3653008 | pubmed:abstractText | This paper shows stage- and tissue-specific global demethylation and remethylation occurring during embryonic development. The egg genome is strikingly undermethylated and the sperm genome relatively methylated. Following a loss of genomic methylation during preimplantation development, embryonic and extraembryonic lineages are progressively and independently methylated to different final extents. Methylation continues postgastrulation and hence could be a mechanism initiating, or confirming, differential programming in the definitive germ layers. It is proposed that much of the methylation observed in somatic tissues acts to stabilize and reinforce prior events that regulate the activity of specific genes, chromosome domains or the X chromosome (in females). Fetal germ cell DNA is markedly undermethylated and we favour the idea that the germ lineage is set aside before the occurrence of extensive methylation of DNA in fetal precursor cells. | lld:pubmed |
pubmed-article:3653008 | pubmed:language | eng | lld:pubmed |
pubmed-article:3653008 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3653008 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:3653008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3653008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3653008 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3653008 | pubmed:month | Mar | lld:pubmed |
pubmed-article:3653008 | pubmed:issn | 0950-1991 | lld:pubmed |
pubmed-article:3653008 | pubmed:author | pubmed-author:LundC JCJ | lld:pubmed |
pubmed-article:3653008 | pubmed:author | pubmed-author:LehnertSS | lld:pubmed |
pubmed-article:3653008 | pubmed:author | pubmed-author:BoubelikMM | lld:pubmed |
pubmed-article:3653008 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3653008 | pubmed:volume | 99 | lld:pubmed |
pubmed-article:3653008 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3653008 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3653008 | pubmed:pagination | 371-82 | lld:pubmed |
pubmed-article:3653008 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
pubmed-article:3653008 | pubmed:meshHeading | pubmed-meshheading:3653008-... | lld:pubmed |
pubmed-article:3653008 | pubmed:meshHeading | pubmed-meshheading:3653008-... | lld:pubmed |
pubmed-article:3653008 | pubmed:meshHeading | pubmed-meshheading:3653008-... | lld:pubmed |
pubmed-article:3653008 | pubmed:meshHeading | pubmed-meshheading:3653008-... | lld:pubmed |
pubmed-article:3653008 | pubmed:meshHeading | pubmed-meshheading:3653008-... | lld:pubmed |
pubmed-article:3653008 | pubmed:meshHeading | pubmed-meshheading:3653008-... | lld:pubmed |
pubmed-article:3653008 | pubmed:meshHeading | pubmed-meshheading:3653008-... | lld:pubmed |
pubmed-article:3653008 | pubmed:meshHeading | pubmed-meshheading:3653008-... | lld:pubmed |
pubmed-article:3653008 | pubmed:meshHeading | pubmed-meshheading:3653008-... | lld:pubmed |
pubmed-article:3653008 | pubmed:meshHeading | pubmed-meshheading:3653008-... | lld:pubmed |
pubmed-article:3653008 | pubmed:meshHeading | pubmed-meshheading:3653008-... | lld:pubmed |
pubmed-article:3653008 | pubmed:year | 1987 | lld:pubmed |
pubmed-article:3653008 | pubmed:articleTitle | Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. | lld:pubmed |
pubmed-article:3653008 | pubmed:affiliation | MRC Mammalian Development Unit, University College London, UK. | lld:pubmed |
pubmed-article:3653008 | pubmed:publicationType | Journal Article | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3653008 | lld:pubmed |