| pubmed-article:3649277 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3649277 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:3649277 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:3649277 | lifeskim:mentions | umls-concept:C0040549 | lld:lifeskim |
| pubmed-article:3649277 | lifeskim:mentions | umls-concept:C0282637 | lld:lifeskim |
| pubmed-article:3649277 | lifeskim:mentions | umls-concept:C0547070 | lld:lifeskim |
| pubmed-article:3649277 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:3649277 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:3649277 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:3649277 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3649277 | pubmed:dateCreated | 1987-9-10 | lld:pubmed |
| pubmed-article:3649277 | pubmed:abstractText | A method of deleting specific cell lineages has been developed that entails microinjection into fertilized eggs of a chimeric gene in which a cell-specific enhancer/promoter is used to drive the expression of a toxic gene product. We show that microinjection of a construct in which the elastase I promoter/enhancer is fused to a gene for diphtheria toxin A polypeptide results in birth of mice lacking a normal pancreas because of expression of the toxin in pancreatic acinar cells. A small pancreatic rudiment, containing islet and duct-like cells, was observed in some of the transgenic mice. This method provides a new approach for studying cell-lineage relationships and for analyzing cellular interactions during development. | lld:pubmed |
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| pubmed-article:3649277 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3649277 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3649277 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3649277 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3649277 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3649277 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3649277 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:3649277 | pubmed:author | pubmed-author:BrinsterR LRL | lld:pubmed |
| pubmed-article:3649277 | pubmed:author | pubmed-author:PalmiterR DRD | lld:pubmed |
| pubmed-article:3649277 | pubmed:author | pubmed-author:MaxwellI HIH | lld:pubmed |
| pubmed-article:3649277 | pubmed:author | pubmed-author:MaxwellFF | lld:pubmed |
| pubmed-article:3649277 | pubmed:author | pubmed-author:BehringerR... | lld:pubmed |
| pubmed-article:3649277 | pubmed:author | pubmed-author:QuaifeC JCJ | lld:pubmed |
| pubmed-article:3649277 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3649277 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:3649277 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:3649277 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3649277 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3649277 | pubmed:pagination | 435-43 | lld:pubmed |
| pubmed-article:3649277 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:3649277 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3649277 | pubmed:articleTitle | Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. | lld:pubmed |
| pubmed-article:3649277 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3649277 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3649277 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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