| pubmed-article:3625671 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3625671 | lifeskim:mentions | umls-concept:C0029408 | lld:lifeskim |
| pubmed-article:3625671 | lifeskim:mentions | umls-concept:C0225369 | lld:lifeskim |
| pubmed-article:3625671 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:3625671 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:3625671 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:3625671 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:3625671 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:3625671 | pubmed:dateCreated | 1987-10-5 | lld:pubmed |
| pubmed-article:3625671 | pubmed:abstractText | Metabolic studies in early experimental osteoarthritis (OA) have shown that the rate of proteoglycan synthesis in the diseased articular cartilage may be markedly enhanced relative to normal; elevated rates of synthesis were however accompanied by increased release of new molecules from the tissue so that the response was apparently non-reparative. Described here are experiments with immature and mature chondrocytes in culture which show that aging of chondrocytes in vivo is accompanied by a marked fall in the capacity of these cells to synthesize link protein and to assemble a proteoglycan-rich matrix. It is suggested that poor deposition of proteoglycan by mature chondrocytes in OA may result from insufficient synthesis of link protein for stabilization of aggregates. | lld:pubmed |
| pubmed-article:3625671 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3625671 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3625671 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3625671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3625671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3625671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3625671 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3625671 | pubmed:month | May | lld:pubmed |
| pubmed-article:3625671 | pubmed:issn | 0315-162X | lld:pubmed |
| pubmed-article:3625671 | pubmed:author | pubmed-author:SandsJ JJJ | lld:pubmed |
| pubmed-article:3625671 | pubmed:author | pubmed-author:BarrachH JHJ | lld:pubmed |
| pubmed-article:3625671 | pubmed:author | pubmed-author:FlanneryC RCR | lld:pubmed |
| pubmed-article:3625671 | pubmed:author | pubmed-author:PlaasA HAH | lld:pubmed |
| pubmed-article:3625671 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3625671 | pubmed:volume | 14 Spec No | lld:pubmed |
| pubmed-article:3625671 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3625671 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3625671 | pubmed:pagination | 16-9 | lld:pubmed |
| pubmed-article:3625671 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3625671 | pubmed:meshHeading | pubmed-meshheading:3625671-... | lld:pubmed |
| pubmed-article:3625671 | pubmed:meshHeading | pubmed-meshheading:3625671-... | lld:pubmed |
| pubmed-article:3625671 | pubmed:meshHeading | pubmed-meshheading:3625671-... | lld:pubmed |
| pubmed-article:3625671 | pubmed:meshHeading | pubmed-meshheading:3625671-... | lld:pubmed |
| pubmed-article:3625671 | pubmed:meshHeading | pubmed-meshheading:3625671-... | lld:pubmed |
| pubmed-article:3625671 | pubmed:meshHeading | pubmed-meshheading:3625671-... | lld:pubmed |
| pubmed-article:3625671 | pubmed:meshHeading | pubmed-meshheading:3625671-... | lld:pubmed |
| pubmed-article:3625671 | pubmed:meshHeading | pubmed-meshheading:3625671-... | lld:pubmed |
| pubmed-article:3625671 | pubmed:meshHeading | pubmed-meshheading:3625671-... | lld:pubmed |
| pubmed-article:3625671 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3625671 | pubmed:articleTitle | The biosynthetic response of the mature chondrocyte in early osteoarthritis. | lld:pubmed |
| pubmed-article:3625671 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3625671 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
