| pubmed-article:3610214 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3610214 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:3610214 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:3610214 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:3610214 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:3610214 | lifeskim:mentions | umls-concept:C0597140 | lld:lifeskim |
| pubmed-article:3610214 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:3610214 | lifeskim:mentions | umls-concept:C0204695 | lld:lifeskim |
| pubmed-article:3610214 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3610214 | pubmed:dateCreated | 1987-9-23 | lld:pubmed |
| pubmed-article:3610214 | pubmed:abstractText | We have examined the effects of protein deprivation on the induction of oral tolerance for systemic antibody and DTH responses to the protein antigen ovalbumin (OVA). Mice were fed 4% or 24% protein diets from weaning and given a single feed of OVA 2 weeks later (short-term deprivation) or after 10 weeks (long-term deprivation). Tolerance for serum antibody responses was more profound in protein-deprived animals than in 24% protein-fed control groups. Conversely, tolerance for DTH responses was impaired in protein-deprived mice. This was demonstrated both for short-term deprivation, where nutritional rehabilitation after OVA feeding was necessary to demonstrate this effect on DTH, and for long-term deprivation. Furthermore, the effect of short-term deprivation on tolerance for DTH responses was similar to that observed after cyclophosphamide pretreatment of OVA-fed mice. Protein deprivation has disparate effects on the humoral and cell-mediated limbs of oral tolerance, and our results support the hypothesis that this regime selectively depletes a population of suppressor T cells responsible for the fine control of DTH tolerance. | lld:pubmed |
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| pubmed-article:3610214 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3610214 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3610214 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3610214 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3610214 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3610214 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:3610214 | pubmed:author | pubmed-author:FergusonAA | lld:pubmed |
| pubmed-article:3610214 | pubmed:author | pubmed-author:GordonMM | lld:pubmed |
| pubmed-article:3610214 | pubmed:author | pubmed-author:LamontA GAG | lld:pubmed |
| pubmed-article:3610214 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3610214 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:3610214 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3610214 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3610214 | pubmed:pagination | 333-7 | lld:pubmed |
| pubmed-article:3610214 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3610214 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3610214 | pubmed:articleTitle | Oral tolerance in protein-deprived mice. I. Profound antibody tolerance but impaired DTH tolerance after antigen feeding. | lld:pubmed |
| pubmed-article:3610214 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3610214 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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