| pubmed-article:3544371 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3544371 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:3544371 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:3544371 | lifeskim:mentions | umls-concept:C0035015 | lld:lifeskim |
| pubmed-article:3544371 | lifeskim:mentions | umls-concept:C0332448 | lld:lifeskim |
| pubmed-article:3544371 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:3544371 | lifeskim:mentions | umls-concept:C1318444 | lld:lifeskim |
| pubmed-article:3544371 | lifeskim:mentions | umls-concept:C1882923 | lld:lifeskim |
| pubmed-article:3544371 | lifeskim:mentions | umls-concept:C1548437 | lld:lifeskim |
| pubmed-article:3544371 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:3544371 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3544371 | pubmed:dateCreated | 1987-3-26 | lld:pubmed |
| pubmed-article:3544371 | pubmed:abstractText | The association of inflammatory cell infiltration with orthotopic rat liver transplant rejection was studied by immunopathologic evaluation of allografts at different time points using high- and low-responder strain combinations. PVG(RT-1c) recipients of ACI (RT-1a) liver transplants had prolonged survival (greater than 100 days) without immunosuppression. In contrast, Lewis (RT-1l) recipients of ACI liver transplants had severe acute rejection with mean survival of 10.7 +/- 0.5 days (n = 9). Graft recipients of both strain combinations, as well as control syngeneic PVG-to-PVG and Lewis-to-Lewis graft recipients were sacrificed at various time points posttransplant. Sections of livers were evaluated in a masked fashion for histologic changes as well as the extent and phenotype of cellular infiltrates, as determined by immunoperoxidase labeling using monoclonal antibodies OX1 (pan leukocyte), W3/13 (pan T cell), W3/25 (T helper cell:Th), and OX8 (T cytotoxic-suppressor:Tc-s). The results suggest that: the intensity and relative distribution of rat hepatic allograft T cell infiltrates at a given time point do not necessarily correlate with eventual outcome; the intensities of W3/25 (Th) and OX1 (pan-leukocyte) cell infiltrates parallel each other in both high- and low-responder strain combinations; the relative ratio of T cells (W3/13) to non-T cells increases over time in low-responder strains but remains relatively constant in high-responder strains during active rejection; and the relative ratio of W3/25:OX8 (Th:Tc-s) decreases in high-responder strains but increases in low-responder strains. | lld:pubmed |
| pubmed-article:3544371 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3544371 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3544371 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3544371 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3544371 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3544371 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3544371 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3544371 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3544371 | pubmed:issn | 0041-1337 | lld:pubmed |
| pubmed-article:3544371 | pubmed:author | pubmed-author:SanfilippoFF | lld:pubmed |
| pubmed-article:3544371 | pubmed:author | pubmed-author:BollingerR... | lld:pubmed |
| pubmed-article:3544371 | pubmed:author | pubmed-author:WolfeJ AJA | lld:pubmed |
| pubmed-article:3544371 | pubmed:author | pubmed-author:KnechtleS JSJ | lld:pubmed |
| pubmed-article:3544371 | pubmed:author | pubmed-author:BurchetteJJ | lld:pubmed |
| pubmed-article:3544371 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3544371 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:3544371 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3544371 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3544371 | pubmed:pagination | 169-72 | lld:pubmed |
| pubmed-article:3544371 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3544371 | pubmed:meshHeading | pubmed-meshheading:3544371-... | lld:pubmed |
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| pubmed-article:3544371 | pubmed:meshHeading | pubmed-meshheading:3544371-... | lld:pubmed |
| pubmed-article:3544371 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3544371 | pubmed:articleTitle | Infiltrating cell phenotypes and patterns associated with hepatic allograft rejection or acceptance. | lld:pubmed |
| pubmed-article:3544371 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3544371 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
