| pubmed-article:3489615 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3489615 | lifeskim:mentions | umls-concept:C0079772 | lld:lifeskim |
| pubmed-article:3489615 | lifeskim:mentions | umls-concept:C0596138 | lld:lifeskim |
| pubmed-article:3489615 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:3489615 | lifeskim:mentions | umls-concept:C0449258 | lld:lifeskim |
| pubmed-article:3489615 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:3489615 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:3489615 | pubmed:dateCreated | 1986-11-17 | lld:pubmed |
| pubmed-article:3489615 | pubmed:abstractText | Primary tumors of X-ray-induced murine T cell lymphomas comprise autocrine, growth factor-dependent cells. We have grown cell lines from primary X-ray-induced thymic lymphomas (PXTLs) under conditions which minimize the progression of the cells from factor dependence to factor independence. All (22) PXTL lines grown secrete a growth factor which supports their own growth and which we will call lymphoma growth factor LGF. LGF-dependent cells are non-tumorigenic or poorly tumorigenic, do not clone in soft agar, have no detectable rearrangements in the c-myc or Pim-1 region and possess near diploid or pseudodiploid karyotypes without evidence for trisomy of chromosomes nos. 15 or 17. PXTL-secreted LGF has no interleukin 1, 2, or 3 activity nor do LGF-secreting cells synthesize detectable IL-1, -2, or -3 mRNA. LGF contains no detectable interferon or GM-CSF activity in specific bioassays. Purified EGF, TGF beta, and interleukin preparations are inactive on LGF-dependent PXTL cells. Thus LGF appears to be a new growth factor that is required for the proliferation of non-progressed T lymphoma cells. Upon progression PXTL cells become growth factor independent, are highly tumorigenic in vivo, clone in soft agar, and assume a near triploid karyotype containing numerous chromosomal aberrations. Thus in X-ray-induced lymphomagenesis an autocrine, LGF-dependent phase precedes the progressed phase characterized by rearrangements in the myc and/or Pim-1 regions as well as by many chromosomal aberrations visible in the karyotype. | lld:pubmed |
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| pubmed-article:3489615 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3489615 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3489615 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3489615 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3489615 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3489615 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:3489615 | pubmed:author | pubmed-author:VogtMM | lld:pubmed |
| pubmed-article:3489615 | pubmed:author | pubmed-author:HaasMM | lld:pubmed |
| pubmed-article:3489615 | pubmed:author | pubmed-author:BogartM HMH | lld:pubmed |
| pubmed-article:3489615 | pubmed:author | pubmed-author:HymanRR | lld:pubmed |
| pubmed-article:3489615 | pubmed:author | pubmed-author:MasonG FGF | lld:pubmed |
| pubmed-article:3489615 | pubmed:author | pubmed-author:Augery-Bourge... | lld:pubmed |
| pubmed-article:3489615 | pubmed:author | pubmed-author:BogenbergerJ... | lld:pubmed |
| pubmed-article:3489615 | pubmed:author | pubmed-author:BuchananM AMA | lld:pubmed |
| pubmed-article:3489615 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3489615 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:3489615 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3489615 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3489615 | pubmed:pagination | 1775-82 | lld:pubmed |
| pubmed-article:3489615 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3489615 | pubmed:meshHeading | pubmed-meshheading:3489615-... | lld:pubmed |
| pubmed-article:3489615 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3489615 | pubmed:articleTitle | Autocrine growth and progression of murine X-ray-induced T cell lymphomas. | lld:pubmed |
| pubmed-article:3489615 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3489615 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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