| pubmed-article:3477317 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3477317 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:3477317 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3477317 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:3477317 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:3477317 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:3477317 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3477317 | lifeskim:mentions | umls-concept:C0163054 | lld:lifeskim |
| pubmed-article:3477317 | lifeskim:mentions | umls-concept:C0070913 | lld:lifeskim |
| pubmed-article:3477317 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:3477317 | pubmed:dateCreated | 1987-11-12 | lld:pubmed |
| pubmed-article:3477317 | pubmed:abstractText | Postimplantation rat embryos (Day 10) were exposed in vitro to teratogenic concentrations of 4-hydroperoxycyclophosphamide, an activated form of cyclophosphamide, and phosphoramide mustard, the major teratogenic metabolite of cyclophosphamide. Following a 5-h exposure to these agents, drug-induced DNA damage was assessed by alkaline elution. Both drugs induced detectable DNA cross-linking at teratogenic concentrations. Alkaline elution combined with proteinase K digestion indicated that approximately half of the DNA cross-linking was DNA-DNA cross-linking and the other half was DNA-protein cross-linking. In addition to DNA cross-linking, phosphoramide mustard produced DNA strand breaks and/or alkaline labile sites. However, 4-hydroperoxycyclophosphamide did not produce detectable DNA strand breaks or alkaline labile sites. Our data also indicate that the induction of abnormal morphogenesis by 4-hydroperoxycyclophosphamide and phosphoramide mustard is correlated with drug-induced DNA cross-linking. | lld:pubmed |
| pubmed-article:3477317 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3477317 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3477317 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3477317 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3477317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3477317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3477317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3477317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3477317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3477317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3477317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3477317 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3477317 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3477317 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:3477317 | pubmed:author | pubmed-author:MirkesP EPE | lld:pubmed |
| pubmed-article:3477317 | pubmed:author | pubmed-author:LittleS ASA | lld:pubmed |
| pubmed-article:3477317 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3477317 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:3477317 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:3477317 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3477317 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3477317 | pubmed:pagination | 5421-6 | lld:pubmed |
| pubmed-article:3477317 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3477317 | pubmed:meshHeading | pubmed-meshheading:3477317-... | lld:pubmed |
| pubmed-article:3477317 | pubmed:meshHeading | pubmed-meshheading:3477317-... | lld:pubmed |
| pubmed-article:3477317 | pubmed:meshHeading | pubmed-meshheading:3477317-... | lld:pubmed |
| pubmed-article:3477317 | pubmed:meshHeading | pubmed-meshheading:3477317-... | lld:pubmed |
| pubmed-article:3477317 | pubmed:meshHeading | pubmed-meshheading:3477317-... | lld:pubmed |
| pubmed-article:3477317 | pubmed:meshHeading | pubmed-meshheading:3477317-... | lld:pubmed |
| pubmed-article:3477317 | pubmed:meshHeading | pubmed-meshheading:3477317-... | lld:pubmed |
| pubmed-article:3477317 | pubmed:meshHeading | pubmed-meshheading:3477317-... | lld:pubmed |
| pubmed-article:3477317 | pubmed:meshHeading | pubmed-meshheading:3477317-... | lld:pubmed |
| pubmed-article:3477317 | pubmed:meshHeading | pubmed-meshheading:3477317-... | lld:pubmed |
| pubmed-article:3477317 | pubmed:meshHeading | pubmed-meshheading:3477317-... | lld:pubmed |
| pubmed-article:3477317 | pubmed:meshHeading | pubmed-meshheading:3477317-... | lld:pubmed |
| pubmed-article:3477317 | pubmed:meshHeading | pubmed-meshheading:3477317-... | lld:pubmed |
| pubmed-article:3477317 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3477317 | pubmed:articleTitle | DNA cross-linking and single-strand breaks induced by teratogenic concentrations of 4-hydroperoxycyclophosphamide and phosphoramide mustard in postimplantation rat embryos. | lld:pubmed |
| pubmed-article:3477317 | pubmed:affiliation | Department of Pediatrics, University of Washington, Seattle 98195. | lld:pubmed |
| pubmed-article:3477317 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3477317 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
