| pubmed-article:3425738 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3425738 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:3425738 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:3425738 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:3425738 | lifeskim:mentions | umls-concept:C0201925 | lld:lifeskim |
| pubmed-article:3425738 | lifeskim:mentions | umls-concept:C0070750 | lld:lifeskim |
| pubmed-article:3425738 | lifeskim:mentions | umls-concept:C1140999 | lld:lifeskim |
| pubmed-article:3425738 | pubmed:issue | 6 Pt 2 | lld:pubmed |
| pubmed-article:3425738 | pubmed:dateCreated | 1988-1-28 | lld:pubmed |
| pubmed-article:3425738 | pubmed:abstractText | Intracellular calcium concentration ([Ca2+]i) was measured with aequorin in ferret and rat aortic strips contracted with phorbol esters. In ferret aorta, 12-deoxyphorbol 13-isobutyrate 20-acetate (DPBA, 1 microM) induced contractions without significantly increasing [Ca2+]i, whereas 21 mM K+ induced smaller contractions with a significant rise in [Ca2+]i. Ca2+-free 2.5 mM ethyleneglycol-bis(beta-aminoethylether)-N,N'-tetraacetic acid (EGTA)-physiological saline solution (PSS) had no effect on DPBA-induced tension, whereas it abolished contractions induced by 66 mM K+. The alpha 1-adrenergic agonist phenylephrine (10(-5) M) induced less than 10% of the tension with no initial [Ca2+]i spike under Ca-free conditions. In rat aorta, both phorbol 12-myristate 13-acetate (PMA, 2 microM) and DPBA (1 microM) induced contractions without increasing [Ca2+]i; Ca2+-free EGTA-PSS or the addition of the calcium channel blocker gallopamil (D600, 1 microM), however, abolished greater than 50% of the tension induced by either phorbol ester with a decrease in [Ca2+]i. These results are consistent with the idea that 1) resting [Ca2+]i is both sufficient and required to support phorbol ester-induced contractions in two vascular smooth muscles, suggesting an increased sensitivity of the contractile apparatus for Ca2+, and 2) there are differences in the mechanisms by which phorbol esters and alpha 1-agonists may activate vascular smooth muscle. | lld:pubmed |
| pubmed-article:3425738 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3425738 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3425738 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3425738 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3425738 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3425738 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:3425738 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:3425738 | pubmed:author | pubmed-author:MorganK GKG | lld:pubmed |
| pubmed-article:3425738 | pubmed:author | pubmed-author:JiangM JMJ | lld:pubmed |
| pubmed-article:3425738 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3425738 | pubmed:volume | 253 | lld:pubmed |
| pubmed-article:3425738 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3425738 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3425738 | pubmed:pagination | H1365-71 | lld:pubmed |
| pubmed-article:3425738 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:3425738 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3425738 | pubmed:articleTitle | Intracellular calcium levels in phorbol ester-induced contractions of vascular muscle. | lld:pubmed |
| pubmed-article:3425738 | pubmed:affiliation | Cardiovascular Division, Charles A. Dana Research Institute, Boston, Massachusetts. | lld:pubmed |
| pubmed-article:3425738 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3425738 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3425738 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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