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pubmed-article:3415656pubmed:abstractTextThe oxygen-consumption rates and the activities of fumarase and beta-hydroxyacyl-CoA dehydrogenase were compared in mitochondria isolated from fetal- and neonatal-rat kidney. Whole-organ ATP, phosphocreatine and creatine contents were determined in parallel. Kidney mitochondrial respiratory rates in the presence of succinate, glutamate/malate and palmitoyl-L-carnitine increased between 21 days post coitum and 1 day post partum, together with activities of oxidative enzymes. However, this postnatal maturation of oxidative metabolism was not yet initiated in mitochondria isolated from kidney 1 h post partum. An increase in ATP and phosphocreatine was observed immediately after delivery; newborn-rat kidney ATP content then remained high, whereas phosphocreatine reserves decreased considerably between 6 h and 1 day post partum. It is concluded that the increase in high-energy phosphate compounds observed at birth is not initially related to an activation of oxidative phosphorylation, and probably involves a transient stimulation of anaerobic glycolysis, while a progressive mitochondrial maturation takes place in the rat kidney during the first day of newborn life.lld:pubmed
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pubmed-article:3415656pubmed:articleTitleEffects of birth on energy metabolism in the rat kidney.lld:pubmed
pubmed-article:3415656pubmed:affiliationLaboratoire de Différenciation Fonctionelle, Université Paris, France.lld:pubmed
pubmed-article:3415656pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3415656pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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