| pubmed-article:3404448 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3404448 | lifeskim:mentions | umls-concept:C0035983 | lld:lifeskim |
| pubmed-article:3404448 | lifeskim:mentions | umls-concept:C0040578 | lld:lifeskim |
| pubmed-article:3404448 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:3404448 | lifeskim:mentions | umls-concept:C0027096 | lld:lifeskim |
| pubmed-article:3404448 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:3404448 | lifeskim:mentions | umls-concept:C1155937 | lld:lifeskim |
| pubmed-article:3404448 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:3404448 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3404448 | pubmed:dateCreated | 1988-9-19 | lld:pubmed |
| pubmed-article:3404448 | pubmed:abstractText | Previous studies have shown that muscarinic activation of airway smooth muscle in low Ca++ solutions increases myosin phosphorylation without increasing tension. Blocking Ca++ influx reduced phosphorylation, but not to basal levels. It was proposed that release of intracellular Ca++ contributed to dissociation of phosphorylation and contraction. To test this hypothesis the effects of ryanodine were studied under similar conditions. Ryanodine (10(-7) to 10(-5) M) antagonized caffeine-induced contraction of canine tracheal smooth muscle. Ryanodine also reduced carbachol-induced contractions and carbachol-induced myosin phosphorylation. The effect of ryanodine on potassium and serotonin-induced contractions was also investigated to test for a nonspecific inhibitory effect. In contrast to the effect on carbachol responses, ryanodine (10(-5) M) potentiated the contractile response to low concentrations of serotonin and potassium, but had no effect on the maximum response to either stimulant. Carbachol (10(-6) M) and ryanodine (10(-5) M) both significantly decreased 45Ca++ content of tracheal muscle. The effect of ryanodine and carbachol together on 45Ca++ content was not greater than either drug alone suggesting that ryanodine reduces the caffeine and carbachol responses by depleting releaseable Ca++ stores. Ryanodine significantly reduced Ca++-induced contraction and myosin phosphorylation in carbachol-stimulated muscle, suggesting that some of the Ca++ responsible for elevated phosphorylation is released from the sarcoplasmic reticulum. | lld:pubmed |
| pubmed-article:3404448 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3404448 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3404448 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3404448 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3404448 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3404448 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3404448 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3404448 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3404448 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:3404448 | pubmed:author | pubmed-author:GerthofferW... | lld:pubmed |
| pubmed-article:3404448 | pubmed:author | pubmed-author:KhoyiM AMA | lld:pubmed |
| pubmed-article:3404448 | pubmed:author | pubmed-author:MurpheyK AKA | lld:pubmed |
| pubmed-article:3404448 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3404448 | pubmed:volume | 246 | lld:pubmed |
| pubmed-article:3404448 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3404448 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3404448 | pubmed:pagination | 585-90 | lld:pubmed |
| pubmed-article:3404448 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:3404448 | pubmed:meshHeading | pubmed-meshheading:3404448-... | lld:pubmed |
| pubmed-article:3404448 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3404448 | pubmed:articleTitle | Inhibition of tracheal smooth muscle contraction and myosin phosphorylation by ryanodine. | lld:pubmed |
| pubmed-article:3404448 | pubmed:affiliation | Department of Pharmacology, University of Nevada School of Medicine, Reno. | lld:pubmed |
| pubmed-article:3404448 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3404448 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3404448 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3404448 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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