| pubmed-article:3367901 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3367901 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3367901 | lifeskim:mentions | umls-concept:C0038317 | lld:lifeskim |
| pubmed-article:3367901 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:3367901 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:3367901 | lifeskim:mentions | umls-concept:C0020365 | lld:lifeskim |
| pubmed-article:3367901 | lifeskim:mentions | umls-concept:C0010798 | lld:lifeskim |
| pubmed-article:3367901 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:3367901 | lifeskim:mentions | umls-concept:C0051441 | lld:lifeskim |
| pubmed-article:3367901 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3367901 | pubmed:dateCreated | 1988-6-23 | lld:pubmed |
| pubmed-article:3367901 | pubmed:abstractText | Rifampicin induces cytochrome P-450 3c, progesterone 16 alpha- and 6 beta-hydroxylation, 17 beta-estradiol 2-hydroxylation, benzo[a] pyrene hydroxylation, and erythromycin N-demethylation in rabbit liver microsomes. Kinetic analysis of the 6 beta-hydroxylation of progesterone as catalyzed by liver microsomes prepared from rifampicin-treated B/J rabbits exhibits a curvilinear double-reciprocal plot, suggestive of substrate activation. Further experimentation demonstrated that alpha-naphthoflavone could augment the catalytic efficiency [Vmax/Km] observed for the 16 alpha- and 6 beta-hydroxylation of progesterone and the 2-hydroxylation of 17 beta-estradiol, whereas erythromycin N-demethylase activity was partially inhibited. Allosteric activation of these steroid hydroxylases by alpha-naphthoflavone is also found for human liver microsomes, indicating that the activation of these enzymes is conserved in man and rabbit. | lld:pubmed |
| pubmed-article:3367901 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3367901 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3367901 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3367901 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3367901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3367901 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3367901 | pubmed:month | May | lld:pubmed |
| pubmed-article:3367901 | pubmed:issn | 0026-895X | lld:pubmed |
| pubmed-article:3367901 | pubmed:author | pubmed-author:JohnsonE FEF | lld:pubmed |
| pubmed-article:3367901 | pubmed:author | pubmed-author:SchwabG EGE | lld:pubmed |
| pubmed-article:3367901 | pubmed:author | pubmed-author:RaucyJ LJL | lld:pubmed |
| pubmed-article:3367901 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3367901 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:3367901 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3367901 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3367901 | pubmed:pagination | 493-9 | lld:pubmed |
| pubmed-article:3367901 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3367901 | pubmed:meshHeading | pubmed-meshheading:3367901-... | lld:pubmed |
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| pubmed-article:3367901 | pubmed:meshHeading | pubmed-meshheading:3367901-... | lld:pubmed |
| pubmed-article:3367901 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3367901 | pubmed:articleTitle | Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone. | lld:pubmed |
| pubmed-article:3367901 | pubmed:affiliation | Department of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, California 92037. | lld:pubmed |
| pubmed-article:3367901 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3367901 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3367901 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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