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pubmed-article:3358806pubmed:abstractTextSix of 9 patients with previously documented adverse reactions to allopurinol exhibited transformation of their peripheral blood lymphocytes when these were exposed in vitro to the allopurinol metabolite, oxypurinol. In 2 of these subjects, intradermal skin challenge was positive at 48 hours with either allopurinol or oxypurinol. The evidence presented suggests that some adverse reactions to allopurinol represent delayed-type hypersensitivity to oxypurinol.lld:pubmed
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pubmed-article:3358806pubmed:articleTitleSome adverse reactions to allopurinol may be mediated by lymphocyte reactivity to oxypurinol.lld:pubmed
pubmed-article:3358806pubmed:affiliationDepartment of Medicine, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia.lld:pubmed
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