| pubmed-article:3357885 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3357885 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3357885 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:3357885 | lifeskim:mentions | umls-concept:C0080296 | lld:lifeskim |
| pubmed-article:3357885 | lifeskim:mentions | umls-concept:C2752630 | lld:lifeskim |
| pubmed-article:3357885 | lifeskim:mentions | umls-concept:C0070750 | lld:lifeskim |
| pubmed-article:3357885 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:3357885 | pubmed:dateCreated | 1988-5-20 | lld:pubmed |
| pubmed-article:3357885 | pubmed:abstractText | Induction of differentiation of the human monoblastic cell line U-937 in vitro by several physiologic and nonphysiologic inducers is accompanied by a rapid decrease in expression of MYC, the endogenous human myc protooncogene. To investigate whether this reduction is a prerequisite for terminal differentiation, we introduced a constitutively expressed v-myc gene into U-937 cells. The results show that constitutive expression of an avian v-myc oncogene does not interfere with phorbol 12-myristate 13-acetate-induced differentiation of U-937 cells early after stimulation. However, after 24 hr the differentiation process is reversed, as judged by a full recovery of the proliferative capacity and reexpression of the immature phenotype, within the next 2-4 days. We conclude that the terminal stage of macrophage differentiation is inhibited in U-937 cells constitutively expressing a v-myc oncogene. | lld:pubmed |
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| pubmed-article:3357885 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3357885 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3357885 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3357885 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3357885 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3357885 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3357885 | pubmed:author | pubmed-author:NilssonKK | lld:pubmed |
| pubmed-article:3357885 | pubmed:author | pubmed-author:PetterssonUU | lld:pubmed |
| pubmed-article:3357885 | pubmed:author | pubmed-author:LarssonL GLG | lld:pubmed |
| pubmed-article:3357885 | pubmed:author | pubmed-author:GidlundMM | lld:pubmed |
| pubmed-article:3357885 | pubmed:author | pubmed-author:VennströmBB | lld:pubmed |
| pubmed-article:3357885 | pubmed:author | pubmed-author:IvhedII | lld:pubmed |
| pubmed-article:3357885 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3357885 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:3357885 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3357885 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3357885 | pubmed:pagination | 2638-42 | lld:pubmed |
| pubmed-article:3357885 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3357885 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3357885 | pubmed:articleTitle | Phorbol ester-induced terminal differentiation is inhibited in human U-937 monoblastic cells expressing a v-myc oncogene. | lld:pubmed |
| pubmed-article:3357885 | pubmed:affiliation | Department of Pathology, University of Uppsala, University Hospital, Sweden. | lld:pubmed |
| pubmed-article:3357885 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3357885 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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