| pubmed-article:3286344 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3286344 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:3286344 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:3286344 | lifeskim:mentions | umls-concept:C0041427 | lld:lifeskim |
| pubmed-article:3286344 | lifeskim:mentions | umls-concept:C0033362 | lld:lifeskim |
| pubmed-article:3286344 | lifeskim:mentions | umls-concept:C0277785 | lld:lifeskim |
| pubmed-article:3286344 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:3286344 | lifeskim:mentions | umls-concept:C1522602 | lld:lifeskim |
| pubmed-article:3286344 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:3286344 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3286344 | pubmed:dateCreated | 1988-6-30 | lld:pubmed |
| pubmed-article:3286344 | pubmed:abstractText | Glucose tolerance and insulin secretion were studied in two groups of non-diabetic identical twins of recently-diagnosed Type 1 (insulin-dependent) diabetic patients: (1) a group of 5 twins with islet cell antibodies, and (2) a group of 6 twins without. Despite similar fasting glucose, insulin and C-peptide concentrations both groups of twins had significantly higher fasting proinsulin concentrations than the control group (p less than 0.05). The twins with complement-fixing islet cell antibodies had reduced glucose tolerance and clearance, whilst the twins without islet cell antibodies did not. Neither group of twins showed any abnormality in insulin, C-peptide or proinsulin response to oral or intravenous glucose. We conclude that increased fasting proinsulin levels precede abnormalities of insulin secretion, and are an early indication of minor B-cell damage in these twins irrespective of their risk of developing diabetes. | lld:pubmed |
| pubmed-article:3286344 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3286344 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3286344 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3286344 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3286344 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3286344 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3286344 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3286344 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3286344 | pubmed:issn | 0012-186X | lld:pubmed |
| pubmed-article:3286344 | pubmed:author | pubmed-author:HalesC NCN | lld:pubmed |
| pubmed-article:3286344 | pubmed:author | pubmed-author:PykeD ADA | lld:pubmed |
| pubmed-article:3286344 | pubmed:author | pubmed-author:LeslieR DRD | lld:pubmed |
| pubmed-article:3286344 | pubmed:author | pubmed-author:TurEE | lld:pubmed |
| pubmed-article:3286344 | pubmed:author | pubmed-author:MillwardB ABA | lld:pubmed |
| pubmed-article:3286344 | pubmed:author | pubmed-author:GrayI PIP | lld:pubmed |
| pubmed-article:3286344 | pubmed:author | pubmed-author:HeatonD ADA | lld:pubmed |
| pubmed-article:3286344 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3286344 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:3286344 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3286344 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3286344 | pubmed:pagination | 182-4 | lld:pubmed |
| pubmed-article:3286344 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:3286344 | pubmed:meshHeading | pubmed-meshheading:3286344-... | lld:pubmed |
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| pubmed-article:3286344 | pubmed:meshHeading | pubmed-meshheading:3286344-... | lld:pubmed |
| pubmed-article:3286344 | pubmed:meshHeading | pubmed-meshheading:3286344-... | lld:pubmed |
| pubmed-article:3286344 | pubmed:meshHeading | pubmed-meshheading:3286344-... | lld:pubmed |
| pubmed-article:3286344 | pubmed:meshHeading | pubmed-meshheading:3286344-... | lld:pubmed |
| pubmed-article:3286344 | pubmed:meshHeading | pubmed-meshheading:3286344-... | lld:pubmed |
| pubmed-article:3286344 | pubmed:meshHeading | pubmed-meshheading:3286344-... | lld:pubmed |
| pubmed-article:3286344 | pubmed:meshHeading | pubmed-meshheading:3286344-... | lld:pubmed |
| pubmed-article:3286344 | pubmed:meshHeading | pubmed-meshheading:3286344-... | lld:pubmed |
| pubmed-article:3286344 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3286344 | pubmed:articleTitle | Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients. | lld:pubmed |
| pubmed-article:3286344 | pubmed:affiliation | Department of Medicine, King's College Hospital, London, UK. | lld:pubmed |
| pubmed-article:3286344 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3286344 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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