| pubmed-article:3264808 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3264808 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:3264808 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:3264808 | lifeskim:mentions | umls-concept:C1156237 | lld:lifeskim |
| pubmed-article:3264808 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:3264808 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:3264808 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3264808 | pubmed:dateCreated | 1989-2-13 | lld:pubmed |
| pubmed-article:3264808 | pubmed:abstractText | Triggering of the T-cell receptor by anti-CD3 monoclonal antibodies (mAb), for example OKT3, induces accessory cell (AC)-dependent interleukin-2 (IL-2) and IL-2 receptor synthesis, and ultimately, T-cell proliferation. We report on the ability of a HLA-class I specific monomorphic mAb, namely FMC16, to inhibit OKT3-driven T-cell mitogenesis. FMC16 was apparently selective for OKT3 because it did not block Concanavalin A (Con A) or mAb Leu-4 induced proliferation. Moreover, this effect was not due to non-specific toxicity nor interference with OKT3 binding. Kinetic analysis showed that FMC16 was inhibitory when added up to 24 hr after initiation of culture. FMC16 drastically reduced both IL-2 production and IL-2 receptor expression, but did not interfere with IL-2 responsiveness. The inhibitory effects were not altered by the addition of exogenous IL-2 if FMC16 was present at the beginning of culture; however, IL-2 did restore proliferation if FMC16 was not added until 3 to 6 hr after initiation of culture. This coincided exactly with an IL-2 mediated increase in the level of TAC-positive cells. Furthermore, T-cell activation triggered by the synergistic action of OKT3 and a phorbol ester (TPA) in the absence of AC was also blocked by FMC16, suggesting that inhibition was not AC-dependent. Taken together, these results indicate that FMC16 interferes with early signals leading to IL-2 production and IL-2 receptor expression and suggest that HLA-class I determinants play an early role in T-cell activation. | lld:pubmed |
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| pubmed-article:3264808 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3264808 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3264808 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3264808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3264808 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3264808 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:3264808 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:3264808 | pubmed:author | pubmed-author:BradleyJJ | lld:pubmed |
| pubmed-article:3264808 | pubmed:author | pubmed-author:BeckmanII | lld:pubmed |
| pubmed-article:3264808 | pubmed:author | pubmed-author:XiaoningXX | lld:pubmed |
| pubmed-article:3264808 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3264808 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:3264808 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3264808 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3264808 | pubmed:pagination | 373-8 | lld:pubmed |
| pubmed-article:3264808 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:3264808 | pubmed:meshHeading | pubmed-meshheading:3264808-... | lld:pubmed |
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| pubmed-article:3264808 | pubmed:meshHeading | pubmed-meshheading:3264808-... | lld:pubmed |
| pubmed-article:3264808 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3264808 | pubmed:articleTitle | Specific inhibition of OKT3-driven T-cell mitogenesis by an anti HLA-class I monoclonal antibody. | lld:pubmed |
| pubmed-article:3264808 | pubmed:affiliation | Department of Clinical Immunology, Flinders Medical Centre and University, Bedford Park, Adelaide, South Australia. | lld:pubmed |
| pubmed-article:3264808 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3264808 | lld:pubmed |
