Linked Life Data

3263370

Source:http://linkedlifedata.com/resource/pubmed/id/3263370

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:3263370rdf:typepubmed:Citationlld:pubmed
pubmed-article:3263370lifeskim:mentionsumls-concept:C0031307lld:lifeskim
pubmed-article:3263370lifeskim:mentionsumls-concept:C0002191lld:lifeskim
pubmed-article:3263370lifeskim:mentionsumls-concept:C0014264lld:lifeskim
pubmed-article:3263370lifeskim:mentionsumls-concept:C0030306lld:lifeskim
pubmed-article:3263370lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:3263370lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:3263370lifeskim:mentionsumls-concept:C0442796lld:lifeskim
pubmed-article:3263370lifeskim:mentionsumls-concept:C1513475lld:lifeskim
pubmed-article:3263370lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:3263370lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:3263370pubmed:issue31lld:pubmed
pubmed-article:3263370pubmed:dateCreated1988-12-2lld:pubmed
pubmed-article:3263370pubmed:abstractTextExpression of alpha 1 proteinase inhibitor (alpha 1-PI) in human mononuclear phagocytes may provide a local mechanism for inactivation of serine proteases at sites of tissue injury, thereby preventing incidental damage to surrounding tissue and allowing for orderly initiation of repair. We have previously shown that serine (neutrophilic or pancreatic) elastase and lipopolysaccharide (LPS) each mediate an increase in the expression of alpha 1-PI in human peripheral blood monocytes and bronchoalveolar macrophages. In this study we demonstrate that elastase and LPS have an additive positive regulatory effect on alpha 1-PI expression. Distinct pretranslational and translational mechanisms of action for elastase and LPS, respectively, account for the additive effect. The possibility that translational regulation of alpha 1-PI by LPS involves a mechanism analogous to that of the yeast gene GCN4 during amino acid starvation and that of the human ferritin gene in response to iron is discussed.lld:pubmed
pubmed-article:3263370pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3263370pubmed:languageenglld:pubmed
pubmed-article:3263370pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3263370pubmed:citationSubsetIMlld:pubmed
pubmed-article:3263370pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3263370pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3263370pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3263370pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3263370pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3263370pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3263370pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3263370pubmed:statusMEDLINElld:pubmed
pubmed-article:3263370pubmed:monthNovlld:pubmed
pubmed-article:3263370pubmed:issn0021-9258lld:pubmed
pubmed-article:3263370pubmed:authorpubmed-author:PerlmutterD...lld:pubmed
pubmed-article:3263370pubmed:authorpubmed-author:PunsalP IPIlld:pubmed
pubmed-article:3263370pubmed:issnTypePrintlld:pubmed
pubmed-article:3263370pubmed:day5lld:pubmed
pubmed-article:3263370pubmed:volume263lld:pubmed
pubmed-article:3263370pubmed:ownerNLMlld:pubmed
pubmed-article:3263370pubmed:authorsCompleteYlld:pubmed
pubmed-article:3263370pubmed:pagination16499-503lld:pubmed
pubmed-article:3263370pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:3263370pubmed:meshHeadingpubmed-meshheading:3263370-...lld:pubmed
pubmed-article:3263370pubmed:meshHeadingpubmed-meshheading:3263370-...lld:pubmed
pubmed-article:3263370pubmed:meshHeadingpubmed-meshheading:3263370-...lld:pubmed
pubmed-article:3263370pubmed:meshHeadingpubmed-meshheading:3263370-...lld:pubmed
pubmed-article:3263370pubmed:meshHeadingpubmed-meshheading:3263370-...lld:pubmed
pubmed-article:3263370pubmed:meshHeadingpubmed-meshheading:3263370-...lld:pubmed
pubmed-article:3263370pubmed:meshHeadingpubmed-meshheading:3263370-...lld:pubmed
pubmed-article:3263370pubmed:meshHeadingpubmed-meshheading:3263370-...lld:pubmed
pubmed-article:3263370pubmed:meshHeadingpubmed-meshheading:3263370-...lld:pubmed
pubmed-article:3263370pubmed:meshHeadingpubmed-meshheading:3263370-...lld:pubmed
pubmed-article:3263370pubmed:meshHeadingpubmed-meshheading:3263370-...lld:pubmed
pubmed-article:3263370pubmed:meshHeadingpubmed-meshheading:3263370-...lld:pubmed
pubmed-article:3263370pubmed:year1988lld:pubmed
pubmed-article:3263370pubmed:articleTitleDistinct and additive effects of elastase and endotoxin on expression of alpha 1 proteinase inhibitor in mononuclear phagocytes.lld:pubmed
pubmed-article:3263370pubmed:affiliationDepartment of Pediatrics, Washington University School of Medicine, Children's Hospital, St. Louis, Missouri 63110.lld:pubmed
pubmed-article:3263370pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3263370pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:3263370pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3263370lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3263370lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3263370lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3263370lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3263370lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3263370lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3263370lld:pubmed