| pubmed-article:3262872 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3262872 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
| pubmed-article:3262872 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:3262872 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:3262872 | lifeskim:mentions | umls-concept:C0162597 | lld:lifeskim |
| pubmed-article:3262872 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:3262872 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:3262872 | lifeskim:mentions | umls-concept:C0006556 | lld:lifeskim |
| pubmed-article:3262872 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:3262872 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:3262872 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:3262872 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:3262872 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:3262872 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:3262872 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:3262872 | pubmed:dateCreated | 1988-11-21 | lld:pubmed |
| pubmed-article:3262872 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3262872 | pubmed:abstractText | Interleukin 6 (IL-6) refers to the gene product that was characterized initially as beta 2 interferon/26-kDa protein produced by human fibroblasts and later was found to be identical to B-cell stimulatory factor 2, hybridoma/plasmacytoma growth factor, and probably hepatocyte-stimulating factor. Using the human IL-6 cDNA as a probe, we have isolated functional cDNA clones from mouse bone marrow stromal cell cDNA libraries. Sequence analysis of the mouse cDNA insert revealed significant homology between the human and mouse IL-6 cDNA clones both at the level of nucleotide (65%) and deduced amino acid (41%) sequences. The NH2-terminal sequence of the deduced protein is identical to a partial NH2-terminal sequence determined previously for a hybridoma/plasmacytoma growth factor and a plasmacytoma growth factor isolated from mouse T cells and macrophages, respectively. The mRNA for mouse IL-6 is expressed in IL-1-treated stromal cells and in activated T-cell and macrophage cell lines. Supernatants from COS-7 monkey cells transfected with the cDNA clone have plasmacytoma growth factor, hepatocyte-stimulating factor, and colony-stimulating factor activities, as well as the ability to support the growth of a factor-dependent myeloid cell line, thus revealing an additional biological activity for IL-6. | lld:pubmed |
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| pubmed-article:3262872 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3262872 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3262872 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3262872 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3262872 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3262872 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3262872 | pubmed:author | pubmed-author:CoffmanR LRL | lld:pubmed |
| pubmed-article:3262872 | pubmed:author | pubmed-author:LeeFF | lld:pubmed |
| pubmed-article:3262872 | pubmed:author | pubmed-author:RennickDD | lld:pubmed |
| pubmed-article:3262872 | pubmed:author | pubmed-author:HILLL WLW | lld:pubmed |
| pubmed-article:3262872 | pubmed:author | pubmed-author:MouldsCC | lld:pubmed |
| pubmed-article:3262872 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3262872 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:3262872 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3262872 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3262872 | pubmed:pagination | 7099-103 | lld:pubmed |
| pubmed-article:3262872 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3262872 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3262872 | pubmed:articleTitle | Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. | lld:pubmed |
| pubmed-article:3262872 | pubmed:affiliation | Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304-1104. | lld:pubmed |
| pubmed-article:3262872 | pubmed:publicationType | Journal Article | lld:pubmed |
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