| pubmed-article:3203329 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3203329 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:3203329 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:3203329 | lifeskim:mentions | umls-concept:C0024314 | lld:lifeskim |
| pubmed-article:3203329 | lifeskim:mentions | umls-concept:C1721101 | lld:lifeskim |
| pubmed-article:3203329 | lifeskim:mentions | umls-concept:C0205282 | lld:lifeskim |
| pubmed-article:3203329 | lifeskim:mentions | umls-concept:C0018966 | lld:lifeskim |
| pubmed-article:3203329 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:3203329 | pubmed:dateCreated | 1989-2-9 | lld:pubmed |
| pubmed-article:3203329 | pubmed:abstractText | The metabolism of heme is impaired in lymphocytes of patients with malignant lymphoproliferative disorders (MLPO). Two of the enzymes of the heme biosynthetic pathway, delta-aminolevulinic acid dehydrase (ALAD) (EC 4.2.1.24) and ferrochelatase (FC) (EC 4.99.1.1) are markedly reduced. The activity of porphobilinogen deaminase (PBGD) (EC 4.3.1.8) is increased. The rate-limiting enzyme of heme biosynthesis in the liver, aminolevulinate synthase (ALAS) (EC 2.3.1.37) remains unchanged although the concentration of total heme in the lymphocytes is markedly reduced. This might reflect a lack of negative feedback inhibition by heme on ALAS activity in this system. | lld:pubmed |
| pubmed-article:3203329 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3203329 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3203329 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3203329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3203329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3203329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3203329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3203329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3203329 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3203329 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:3203329 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:3203329 | pubmed:author | pubmed-author:AtsmonAA | lld:pubmed |
| pubmed-article:3203329 | pubmed:author | pubmed-author:EpsteinOO | lld:pubmed |
| pubmed-article:3203329 | pubmed:author | pubmed-author:SchoenfeldNN | lld:pubmed |
| pubmed-article:3203329 | pubmed:author | pubmed-author:LahavMM | lld:pubmed |
| pubmed-article:3203329 | pubmed:author | pubmed-author:ShaklaiMM | lld:pubmed |
| pubmed-article:3203329 | pubmed:author | pubmed-author:MametRR | lld:pubmed |
| pubmed-article:3203329 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3203329 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:3203329 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:3203329 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3203329 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3203329 | pubmed:pagination | 43-8 | lld:pubmed |
| pubmed-article:3203329 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3203329 | pubmed:meshHeading | pubmed-meshheading:3203329-... | lld:pubmed |
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| pubmed-article:3203329 | pubmed:meshHeading | pubmed-meshheading:3203329-... | lld:pubmed |
| pubmed-article:3203329 | pubmed:meshHeading | pubmed-meshheading:3203329-... | lld:pubmed |
| pubmed-article:3203329 | pubmed:meshHeading | pubmed-meshheading:3203329-... | lld:pubmed |
| pubmed-article:3203329 | pubmed:meshHeading | pubmed-meshheading:3203329-... | lld:pubmed |
| pubmed-article:3203329 | pubmed:meshHeading | pubmed-meshheading:3203329-... | lld:pubmed |
| pubmed-article:3203329 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3203329 | pubmed:articleTitle | The heme biosynthetic pathway in lymphocytes of patients with malignant lymphoproliferative disorders. | lld:pubmed |
| pubmed-article:3203329 | pubmed:affiliation | Laboratory of Biochemical Pharmacology, Beilinson Medical Center, Petah Tiqva, Israel. | lld:pubmed |
| pubmed-article:3203329 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3203329 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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