| pubmed-article:3156808 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3156808 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:3156808 | lifeskim:mentions | umls-concept:C1293122 | lld:lifeskim |
| pubmed-article:3156808 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:3156808 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:3156808 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:3156808 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:3156808 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:3156808 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:3156808 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:3156808 | pubmed:dateCreated | 1985-5-20 | lld:pubmed |
| pubmed-article:3156808 | pubmed:abstractText | Previous studies have shown that monoclonal antibody AF3.44.4 has specificity for a constant region determinant on mouse antigen-specific helper factors and that it also binds to cultured T cells with functional helper cell characteristics. The antibody synergizes with antigen to enhance in vitro antibody responses; here we demonstrate that it will also enhance cell-mediated responses in vitro such as in the generation of proliferating cells in mixed lymphocyte responses and in the generation of specific killer cells in cytotoxic T lymphocyte cultures. The mechanism of AF3.44.4-generated enhancement was investigated. Increased levels of the lymphokines IL-2 and BCDF were detected in supernatants of AF3.44.4-treated cultures but the antibody itself could not replace interleukin-2 (IL-2), and would not stimulate primed cells in the absence of antigen. This type of monoclonal antibody which augments immunological responses in an antigen-dependent fashion may provide a new class of immunostimulant and a new approach to augmenting the responses of weak immunogens. | lld:pubmed |
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| pubmed-article:3156808 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3156808 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3156808 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3156808 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3156808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3156808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3156808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3156808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3156808 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3156808 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3156808 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:3156808 | pubmed:author | pubmed-author:FeldmannMM | lld:pubmed |
| pubmed-article:3156808 | pubmed:author | pubmed-author:EdwardsSS | lld:pubmed |
| pubmed-article:3156808 | pubmed:author | pubmed-author:SunshineG HGH | lld:pubmed |
| pubmed-article:3156808 | pubmed:author | pubmed-author:JamesR FRF | lld:pubmed |
| pubmed-article:3156808 | pubmed:author | pubmed-author:MaudsleyD JDJ | lld:pubmed |
| pubmed-article:3156808 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3156808 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:3156808 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3156808 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3156808 | pubmed:pagination | 693-700 | lld:pubmed |
| pubmed-article:3156808 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3156808 | pubmed:meshHeading | pubmed-meshheading:3156808-... | lld:pubmed |
| pubmed-article:3156808 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3156808 | pubmed:articleTitle | Augmentation of cell-mediated responses in vitro by a monoclonal anti-helper factor antibody. | lld:pubmed |
| pubmed-article:3156808 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3156808 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3156808 | lld:pubmed |
