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pubmed-article:3117861pubmed:abstractTextThe coronary lesion in unstable angina consists of disrupted atherosclerotic plaque with nonocclusive intraluminal thrombus, which frequently persists despite heparin anticoagulation. A 12 hour infusion of recombinant tissue-type plasminogen activator combined with heparin effectively lyses the thrombus and stabilizes the clinical syndrome but is associated with a high incidence of bleeding. Therapeutic schemes of thrombolytic therapy associated with a lower bleeding frequency may be useful for the treatment of unstable angina.lld:pubmed
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pubmed-article:3117861pubmed:articleTitleThrombolytic therapy for unstable angina pectoris: rationale and results.lld:pubmed
pubmed-article:3117861pubmed:affiliationCardiac Division, Massachusetts General Hospital, Boston 02114.lld:pubmed
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