| pubmed-article:3107559 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3107559 | lifeskim:mentions | umls-concept:C0018183 | lld:lifeskim |
| pubmed-article:3107559 | lifeskim:mentions | umls-concept:C1512310 | lld:lifeskim |
| pubmed-article:3107559 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:3107559 | lifeskim:mentions | umls-concept:C0043791 | lld:lifeskim |
| pubmed-article:3107559 | lifeskim:mentions | umls-concept:C0599739 | lld:lifeskim |
| pubmed-article:3107559 | lifeskim:mentions | umls-concept:C2245662 | lld:lifeskim |
| pubmed-article:3107559 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:3107559 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:3107559 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3107559 | pubmed:dateCreated | 1987-6-11 | lld:pubmed |
| pubmed-article:3107559 | pubmed:abstractText | In dimethylsulfoxide-differentiated HL60 granulocytes, the chemotactic peptide N-formyl-Met-Leu-Phe (FMLP) augments arachidonic acid (AA) release via phospholipase A2 activity induced by the Ca2+-ionophore, A23187. Evidence indicates that this augmentation is mediated by diacylglycerols formed endogenously during FMLP receptor activation: The augmentation is mimicked by the synthetic diglyceride 1-oleoyl-2-acetyl-glycerol (OAG) and the tumor promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate; Pertussis toxin inhibits FMLP-induced augmentation but not OAG-induced augmentation: At suboptimal concentrations FMLP and OAG act cooperatively to augment ionophore A23187-induced AA release but not at optimal concentrations. These data indicate that phospholipase A2 activation in FMLP-stimulated HL60 granulocytes involves cooperative interactions between diacylglycerol formed endogenously and Ca2+. Interestingly, this effect of diacylglycerol appears not to be mediated by protein kinase C, since a specific protein kinase C inhibitor, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7) does not inhibit receptor-mediated release of AA by stimulated HL60 granulocytes. | lld:pubmed |
| pubmed-article:3107559 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3107559 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3107559 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3107559 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3107559 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:3107559 | pubmed:author | pubmed-author:SiegelM IMI | lld:pubmed |
| pubmed-article:3107559 | pubmed:author | pubmed-author:BillahM MMM | lld:pubmed |
| pubmed-article:3107559 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3107559 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:3107559 | pubmed:volume | 144 | lld:pubmed |
| pubmed-article:3107559 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3107559 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3107559 | pubmed:pagination | 683-91 | lld:pubmed |
| pubmed-article:3107559 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:3107559 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3107559 | pubmed:articleTitle | Phospholipase A2 activation in chemotactic peptide-stimulated HL60 granulocytes: synergism between diacylglycerol and Ca2+ in a protein kinase C-independent mechanism. | lld:pubmed |
| pubmed-article:3107559 | pubmed:publicationType | Journal Article | lld:pubmed |
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