| pubmed-article:3103124 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:3103124 | lifeskim:mentions | umls-concept:C1510707 | lld:lifeskim |
| pubmed-article:3103124 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:3103124 | lifeskim:mentions | umls-concept:C0441635 | lld:lifeskim |
| pubmed-article:3103124 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:3103124 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:3103124 | lifeskim:mentions | umls-concept:C0003765 | lld:lifeskim |
| pubmed-article:3103124 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:3103124 | lifeskim:mentions | umls-concept:C0439828 | lld:lifeskim |
| pubmed-article:3103124 | lifeskim:mentions | umls-concept:C0205144 | lld:lifeskim |
| pubmed-article:3103124 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:3103124 | pubmed:dateCreated | 1987-4-1 | lld:pubmed |
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| pubmed-article:3103124 | pubmed:abstractText | The germ-line elements for the variable (V) and joining (J) regions of the kappa chains (V kappa-Ars, J kappa 1) that give rise to the productive allele for the A/J mouse light chains of Ars-A monoclonal antibodies (directed against the hapten p-azophenylarsonate) have been cloned and sequenced as well as a rearranged Ars-A light chain gene. Using the V kappa-Ars gene as a hybridization probe, we provide evidence that the V kappa 10 family is relatively small and that only one member gives rise to the productive allele in all Ars-A antibodies. An unusual feature of Ars-A light chains is that all contain an arginine at position 96, the V-J junctional position. We had shown by chain recombination that arginine-96 was essential for antigen binding. In the present study, an arginine codon was not found either at the 3' end of the V kappa-Ars gene segment or at the 5' end of J kappa 1. However, an arginine codon (CGG) can easily be generated by recombination between these two germ-line elements. Thus, we document that junctional diversity through intracodonic recombination can be crucial to the antibody binding function of the resulting molecule. | lld:pubmed |
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| pubmed-article:3103124 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3103124 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3103124 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3103124 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3103124 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3103124 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3103124 | pubmed:author | pubmed-author:CapraJ DJD | lld:pubmed |
| pubmed-article:3103124 | pubmed:author | pubmed-author:SanyJJ | lld:pubmed |
| pubmed-article:3103124 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3103124 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:3103124 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3103124 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3103124 | pubmed:pagination | 1085-9 | lld:pubmed |
| pubmed-article:3103124 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3103124 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3103124 | pubmed:articleTitle | V kappa and J kappa gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions. | lld:pubmed |
| pubmed-article:3103124 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3103124 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3103124 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:692165 | entrezgene:pubmed | pubmed-article:3103124 | lld:entrezgene |
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