| pubmed-article:3025258 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3025258 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:3025258 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3025258 | lifeskim:mentions | umls-concept:C0042842 | lld:lifeskim |
| pubmed-article:3025258 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:3025258 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3025258 | lifeskim:mentions | umls-concept:C1256369 | lld:lifeskim |
| pubmed-article:3025258 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:3025258 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:3025258 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3025258 | pubmed:dateCreated | 1987-1-29 | lld:pubmed |
| pubmed-article:3025258 | pubmed:abstractText | We studied the effects of vitamin A deficiency and repletion on rat insulin release and islet cellular retinol binding protein (CRBP) and cellular retinoic acid binding protein (CRABP). Biphasic insulin release from vitamin A-deficient perifused islets was markedly impaired. Release remained impaired with retinoic acid (RA) repletion, 2 micrograms/g diet compared to release from islets of rats repleted with retinol in the form of retinyl palmitate, 4 micrograms/g diet. Release normalized with RA, 8 micrograms/g diet. Vitamin A deficiency did not affect islet insulin content, cell size, number or structure. In vivo, vitamin A-deficient rats had impaired glucose-induced acute insulin release and glucose intolerance, which improved with repletion. Normal islets had greater concentrations of CRBP than CRABP; vitamin A deficiency reduced CRBP but not CRABP levels. We conclude retinol is required for normal insulin secretion. Retinoic acid may substitute for retinol in this function. | lld:pubmed |
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| pubmed-article:3025258 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3025258 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:3025258 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3025258 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3025258 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:3025258 | pubmed:author | pubmed-author:ThompsonDD | lld:pubmed |
| pubmed-article:3025258 | pubmed:author | pubmed-author:ChertowB SBS | lld:pubmed |
| pubmed-article:3025258 | pubmed:author | pubmed-author:MedaPP | lld:pubmed |
| pubmed-article:3025258 | pubmed:author | pubmed-author:BlanerW SWS | lld:pubmed |
| pubmed-article:3025258 | pubmed:author | pubmed-author:BaranetskyN... | lld:pubmed |
| pubmed-article:3025258 | pubmed:author | pubmed-author:SivitzW IWI | lld:pubmed |
| pubmed-article:3025258 | pubmed:author | pubmed-author:CordleM BMB | lld:pubmed |
| pubmed-article:3025258 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3025258 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:3025258 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3025258 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3025258 | pubmed:pagination | 163-9 | lld:pubmed |
| pubmed-article:3025258 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:3025258 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3025258 | pubmed:articleTitle | Effects of vitamin A deficiency and repletion on rat insulin secretion in vivo and in vitro from isolated islets. | lld:pubmed |
| pubmed-article:3025258 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3025258 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3025258 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3025258 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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