| pubmed-article:3017707 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3017707 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:3017707 | lifeskim:mentions | umls-concept:C0063699 | lld:lifeskim |
| pubmed-article:3017707 | lifeskim:mentions | umls-concept:C1158770 | lld:lifeskim |
| pubmed-article:3017707 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:3017707 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:3017707 | lifeskim:mentions | umls-concept:C2827063 | lld:lifeskim |
| pubmed-article:3017707 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:3017707 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:3017707 | pubmed:dateCreated | 1986-10-1 | lld:pubmed |
| pubmed-article:3017707 | pubmed:abstractText | We show that human glioblastoma cells, moving from exponential growth into a state of density-dependent growth arrest, demonstrate a 7-fold drop in the total number of alpha-IFN-receptors expressed per cell. This loss of receptor activity was not seen when cells were grown in the presence of anti-alpha-IFN-monoclonal antibody. The active binding sites expressed on the arrested cell population were of reduced affinity for IFN, relative to the high-affinity sites expressed on the growing cells, resulting in a 3-fold lower initial rate of IFN-binding to the arrested cells. We exploited this difference to investigate the relationship between IFN receptor binding and induced gene transcription. As determined by nuclear run-off assays, the transcriptional response of both the gene family 1-8 and 2-5A synthetase to IFN treatment also showed a 3-fold reduction in density-arrested cells. Longer-term (0-8 h) induction and down-regulation of gene transcription in IFN-treated cells closely followed the binding to, and down-regulation of, cell surface-localized IFN receptors. Furthermore, inhibition of the intracellular breakdown of IFN did not affect transcriptional responses to IFN. Thus transcription of these IFN-induced genes is closely linked to surface receptor occupancy and is most likely mediated by transmembrane signals alone. | lld:pubmed |
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| pubmed-article:3017707 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3017707 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3017707 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3017707 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3017707 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3017707 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:3017707 | pubmed:author | pubmed-author:WilliamsB RBR | lld:pubmed |
| pubmed-article:3017707 | pubmed:author | pubmed-author:HanniganGG | lld:pubmed |
| pubmed-article:3017707 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3017707 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:3017707 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3017707 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3017707 | pubmed:pagination | 1607-13 | lld:pubmed |
| pubmed-article:3017707 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3017707 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3017707 | pubmed:articleTitle | Transcriptional regulation of interferon-responsive genes is closely linked to interferon receptor occupancy. | lld:pubmed |
| pubmed-article:3017707 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3017707 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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