| pubmed-article:3005628 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3005628 | lifeskim:mentions | umls-concept:C0014665 | lld:lifeskim |
| pubmed-article:3005628 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:3005628 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:3005628 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3005628 | pubmed:dateCreated | 1986-3-28 | lld:pubmed |
| pubmed-article:3005628 | pubmed:abstractText | The arrangement and location of homologous DNA sequences within the genomes of equine herpesvirus type 1 (EHV-1) and EHV-3 were investigated by using Southern blot hybridization analyses conducted under stringent conditions. Recombinant plasmid libraries comprising 95 and 84% of the EHV-1 and EHV-3 genomes, respectively, were labeled with 32P-deoxynucleotides by nick translation and were used as probes in filter hybridization studies. The DNA homology between the EHV-1 and EHV-3 genomes was dispersed throughout the genomes in a colinear arrangement. Significant hybridization was detected between the EHV-1 short region inverted repeat sequences, which are known to encode immediate early transcripts, and the corresponding EHV-3 inverted repeat sequences. Interestingly, probes derived from the EHV-1 heterogeneous region, which is adjacent to the EHV-1 short region, hybridized strongly to EHV-3 DNA sequences within a similar genomic location, but did not reveal any corresponding heterogeneity within the EHV-3 genome. Our results demonstrated that there is a highly conserved evolutionary relationship between EHV-1 and EHV-3 and provided the foundation for further investigations to determine whether similarities in protein function underpin the genetic relatedness between these two herpesviruses. | lld:pubmed |
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| pubmed-article:3005628 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3005628 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3005628 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3005628 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3005628 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3005628 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:3005628 | pubmed:author | pubmed-author:O'CallaghanD... | lld:pubmed |
| pubmed-article:3005628 | pubmed:author | pubmed-author:BaumannR PRP | lld:pubmed |
| pubmed-article:3005628 | pubmed:author | pubmed-author:SullivanD CDC | lld:pubmed |
| pubmed-article:3005628 | pubmed:author | pubmed-author:StaczekJJ | lld:pubmed |
| pubmed-article:3005628 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3005628 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:3005628 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3005628 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3005628 | pubmed:pagination | 816-25 | lld:pubmed |
| pubmed-article:3005628 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:3005628 | pubmed:meshHeading | pubmed-meshheading:3005628-... | lld:pubmed |
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| pubmed-article:3005628 | pubmed:meshHeading | pubmed-meshheading:3005628-... | lld:pubmed |
| pubmed-article:3005628 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3005628 | pubmed:articleTitle | Genetic relatedness and colinearity of genomes of equine herpesvirus types 1 and 3. | lld:pubmed |
| pubmed-article:3005628 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3005628 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3005628 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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