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pubmed-article:3002856pubmed:abstractTextalpha 1-Adrenergic activation of isolated brown adipocytes causes a rapid mobilization of intracellular Ca2+. The cells also respond with an increased turnover of inositol lipids. The present work demonstrates that alpha 1-adrenergic stimulation of brown adipocytes results in phospholipase C-mediated breakdown of phosphatidylinositol bisphosphate to form inositol trisphosphate. The rate of appearance of inositol trisphosphate is sufficiently rapid for it to mediate or contribute to Ca2+ mobilization in these cells.lld:pubmed
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pubmed-article:3002856pubmed:articleTitleAlpha 1-adrenergic activation of brown adipocytes leads to an increased formation of inositol polyphosphates.lld:pubmed
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