| pubmed-article:2988682 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2988682 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:2988682 | lifeskim:mentions | umls-concept:C0009368 | lld:lifeskim |
| pubmed-article:2988682 | lifeskim:mentions | umls-concept:C0205108 | lld:lifeskim |
| pubmed-article:2988682 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:2988682 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2988682 | lifeskim:mentions | umls-concept:C0599668 | lld:lifeskim |
| pubmed-article:2988682 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2988682 | pubmed:dateCreated | 1985-7-29 | lld:pubmed |
| pubmed-article:2988682 | pubmed:abstractText | The effect of gamma-aminobutyric acid (GABA) administration was studied in both in vitro and in vivo preparations of the guinea-pig distal colon. In in vitro preparations GABA (10(-7) - 10(-3) M) elicited a dose-dependent relaxation; a decrease in the spontaneous contractions was sometimes observed. The effect of GABA was mimicked by (-)-baclofen, which gave a dose-response curve overlapping that of GABA, while (+)-baclofen was about one hundred times less potent. The relaxation responses induced by the above drugs were antagonized by 5-aminovaleric acid (5 X 10(-4) M), which did not affect adenosine-induced relaxation, but they were insensitive to bicuculline (10(-5) M) and picrotoxin (10(-5) M). Moreover, they were prevented by tetrodotoxin (6 X 10(-7) M). In hyoscine (10(-7) M)-pretreated preparations, GABA still evoked a small relaxation response (approx. 10% of the maximum) that was bicuculline-sensitive. Desensitization to GABA (10(-5) M) was observed. A specific cross-desensitization occurred between GABA (10(-5) M) and (-)-baclofen (10(-5) M). In in vivo preparations, GABA (10 mumol kg-1) and (-)-baclofen (5 mumol kg-1) produced a dose-related inhibition of basal tone, while (+)-baclofen (5 mumol kg-1) had much less effect (about 25%). A decrease in the spontaneous contractions was sometimes observed. The relaxant effect of GABA and (-)-baclofen persisted in guinea-pigs pretreated (1-2 min) with picrotoxin (1.6 mumol kg-1), whereas it was significantly reduced in animals injected 1 min beforehand with 5-aminovaleric acid (0.2 mmol). The maximal relaxant effect induced by GABA and (-)-baclofen did not differ from that of atropine (0.9 mumol kg-1) and after atropine administration GABA had no further inhibitory effect. Relaxation responses induced by GABA and (-)-baclofen still occurred after blockade of nicotinic receptors by hexamethonium (0.17 mmol kg-1), which itself caused an increase in the basal tone. When the tone was increased by topical application of physostigmine (40 micrograms), GABA and (-)-baclofen induced a greater relaxation than that obtained in basal conditions. It is concluded that GABA, both in vitro and in vivo administration, inhibits cholinergic tone in guinea-pig distal colon and that this effect is mediated mainly by activation of GABAB receptors. Further experiments are required to ascertain the possible physiological role of a GABA-releasing neuronal system in the colon in vivo. | lld:pubmed |
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| pubmed-article:2988682 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2988682 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2988682 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2988682 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2988682 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:2988682 | pubmed:author | pubmed-author:GiottiAA | lld:pubmed |
| pubmed-article:2988682 | pubmed:author | pubmed-author:ZillettiLL | lld:pubmed |
| pubmed-article:2988682 | pubmed:author | pubmed-author:MaggiC ACA | lld:pubmed |
| pubmed-article:2988682 | pubmed:author | pubmed-author:LuzziSS | lld:pubmed |
| pubmed-article:2988682 | pubmed:author | pubmed-author:SpagnesiSS | lld:pubmed |
| pubmed-article:2988682 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2988682 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:2988682 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2988682 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2988682 | pubmed:pagination | 883-95 | lld:pubmed |
| pubmed-article:2988682 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2988682 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2988682 | pubmed:articleTitle | Modulatory activity of GABAB receptors on cholinergic tone in guinea-pig distal colon. | lld:pubmed |
| pubmed-article:2988682 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2988682 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2988682 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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