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pubmed-article:2971553pubmed:abstractTextSuppression of induced experimental autoimmune thyroiditis can be consistently transferred with spleen cells to syngeneic recipients, provided they are first treated with 200 rads irradiation. Treatment with anti-Thy-1 in vivo immediately prior to transfer abrogates the suppression, while depleting B cells has no effect. The in situ induced tolerance can be prevented by treatment with monoclonal antibodies to the Ly-1 or L3T4 molecules either prior to or post tolerization. Anti-Ly-2 treatment has no effect. In the transfer, again treatment of donors with anti-L3T4 prior to transfer prevents the demonstration of suppression in the recipients, while anti-Ly-2 does not affect suppression. These data suggest that the suppression is being mediated either by a CD4+ T suppressor cell or a CD4+ suppressor inducer cell. Preliminary experiments do not support the possibility of a CD8+ suppressor cell being activated in the recipient.lld:pubmed
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pubmed-article:2971553pubmed:articleTitlePhenotypic characteristics of cells involved in induced suppression to murine experimental autoimmune thyroiditis.lld:pubmed
pubmed-article:2971553pubmed:affiliationDepartment of Immunology, Middlesex Hospital Medical School, London, GB.lld:pubmed
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