| pubmed-article:2966401 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2966401 | lifeskim:mentions | umls-concept:C1304649 | lld:lifeskim |
| pubmed-article:2966401 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:2966401 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2966401 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:2966401 | lifeskim:mentions | umls-concept:C0243127 | lld:lifeskim |
| pubmed-article:2966401 | lifeskim:mentions | umls-concept:C1155927 | lld:lifeskim |
| pubmed-article:2966401 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:2966401 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:2966401 | lifeskim:mentions | umls-concept:C0443331 | lld:lifeskim |
| pubmed-article:2966401 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:2966401 | pubmed:dateCreated | 1988-6-9 | lld:pubmed |
| pubmed-article:2966401 | pubmed:abstractText | The effect of Ca2+ upon the rate constant of force redevelopment following a period of isotonic shortening with immediate restretch to the starting sarcomere length was studied in rabbit psoas fibers at 5 degrees C. Control experiments support the assumption that the rate constant of force redevelopment represents isometric cross-bridge turnover kinetics (fapp + gapp), where fapp and gapp are the rate constants characterizing the transitions from the non-force-generating states to the force-generating states and back to the non-force-generating states, respectively. Parallel measurements of the rate constant of force redevelopment and of force, stiffness, and fiber ATPase during isometric contraction allow the effect of Ca2+ upon fapp and gapp to be determined. Analysis reveals that Ca2+ has a marked effect upon fapp, while gapp remains approximately unchanged. Furthermore, in the range above 25-30% of maximum Ca2+ activation, regulation of force, stiffness, and ATPase is mediated through changes in fapp. Below this range, however, it cannot be ruled out that, in addition, cross-bridges are also switched in and out of the turnover process ("recruitment"). As a consequence of regulation through turnover kinetics, both Ca2+ sensitivity and the slope of force-pCa (-log[Ca2+]) relations are shown to be affected by the ratio fapp/gapp, which may represent an important mechanism of modulation of contractile function in addition to modulation through changes within the regulatory protein system. | lld:pubmed |
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| pubmed-article:2966401 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2966401 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2966401 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2966401 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2966401 | pubmed:month | May | lld:pubmed |
| pubmed-article:2966401 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2966401 | pubmed:author | pubmed-author:BrennerBB | lld:pubmed |
| pubmed-article:2966401 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2966401 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:2966401 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2966401 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2966401 | pubmed:pagination | 3265-9 | lld:pubmed |
| pubmed-article:2966401 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2966401 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2966401 | pubmed:articleTitle | Effect of Ca2+ on cross-bridge turnover kinetics in skinned single rabbit psoas fibers: implications for regulation of muscle contraction. | lld:pubmed |
| pubmed-article:2966401 | pubmed:affiliation | Institute of Physiology II, University of Tübingen, Federal Republic of Germany. | lld:pubmed |
| pubmed-article:2966401 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2966401 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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