| pubmed-article:2966150 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2966150 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:2966150 | lifeskim:mentions | umls-concept:C0205102 | lld:lifeskim |
| pubmed-article:2966150 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:2966150 | lifeskim:mentions | umls-concept:C1704686 | lld:lifeskim |
| pubmed-article:2966150 | lifeskim:mentions | umls-concept:C1521721 | lld:lifeskim |
| pubmed-article:2966150 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:2966150 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2966150 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:2966150 | pubmed:dateCreated | 1988-6-6 | lld:pubmed |
| pubmed-article:2966150 | pubmed:abstractText | The role of eukaryotic initiation factor (eIF)4B in translation is somewhat uncertain, although it appears to stimulate a variety of activities of eIF-4A and eIF-4F. Using the model RNA-dependent ATP hydrolysis assay, the ability of eIF-4B to stimulate eIF-4A and eIF-4F was investigated. The most dramatic effect of eIF-4B is to increase the affinity of eIF-4A for RNA; no effect is seen on the affinity of eIF-4A for ATP. This is not the case for eIF-4F where stimulation occurs primarily through an increase in Vmax and not a change in the affinity for RNA. The finding that eIF-4A and eIF-4B can bind to an mRNA (lacking in secondary structure), with essentially the same degree of effectiveness and affinity as would occur for natural mRNAs in the presence of eIF-4A, eIF-4B, and eIF-4F, suggests a possible role for eIF-4A and eIF-4B in both cap-independent and internal initiation. | lld:pubmed |
| pubmed-article:2966150 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2966150 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2966150 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2966150 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2966150 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2966150 | pubmed:month | May | lld:pubmed |
| pubmed-article:2966150 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:2966150 | pubmed:author | pubmed-author:MerrickW CWC | lld:pubmed |
| pubmed-article:2966150 | pubmed:author | pubmed-author:DeverT ETE | lld:pubmed |
| pubmed-article:2966150 | pubmed:author | pubmed-author:AbramsonR DRD | lld:pubmed |
| pubmed-article:2966150 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2966150 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:2966150 | pubmed:volume | 263 | lld:pubmed |
| pubmed-article:2966150 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2966150 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2966150 | pubmed:pagination | 6016-9 | lld:pubmed |
| pubmed-article:2966150 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2966150 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2966150 | pubmed:articleTitle | Biochemical evidence supporting a mechanism for cap-independent and internal initiation of eukaryotic mRNA. | lld:pubmed |
| pubmed-article:2966150 | pubmed:affiliation | Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106. | lld:pubmed |
| pubmed-article:2966150 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2966150 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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