| pubmed-article:2960952 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2960952 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2960952 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:2960952 | lifeskim:mentions | umls-concept:C0020676 | lld:lifeskim |
| pubmed-article:2960952 | lifeskim:mentions | umls-concept:C1325607 | lld:lifeskim |
| pubmed-article:2960952 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:2960952 | lifeskim:mentions | umls-concept:C0117002 | lld:lifeskim |
| pubmed-article:2960952 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:2960952 | lifeskim:mentions | umls-concept:C1879746 | lld:lifeskim |
| pubmed-article:2960952 | lifeskim:mentions | umls-concept:C1547011 | lld:lifeskim |
| pubmed-article:2960952 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:2960952 | pubmed:dateCreated | 1988-1-15 | lld:pubmed |
| pubmed-article:2960952 | pubmed:abstractText | The effects of hypothyroidism on structural and functional properties of the actomyosin-ATPase complex of rat fast-twitch gastrocnemius muscle were examined and related to energetic and mechanical parameters. Hypothyroidism resulted in the appearance of a small band of the myosin heavy chain subunit of the slow form (MHCs) 8% of total MHC) which was absent in the euthyroid group. This observation corresponded with lower activities of myofibrillar ATPase (-14%) and Ca-activated myosin ATPase (-9%) in the hypothyroid group, although these changes were not significant. No effect of hypothyroidism on the Ca2+-sensitivity of the myofibrillar-ATPase activity was observed and tetanic force was not changed. Twitch force, however, was significantly increased by hypothyroidism. The degree of myosin P-light chain phosphorylation (percentage of total amount of P-light chain) determined after 5 and 10 s of tetanic stimulation (130 Hz, 35 degrees C), respectively, proved to be significantly lower in the hypothyroid group (5 s: 57%; 10 s: 61%) vs the euthyroid group (5 s: 79%; 10 s: 82%). There was no difference in P-light chain phosphorylation at rest between eu- and hypothyroids. The results suggest that a decreased actomyosin-ATPase activity can only in part contribute to the 30% lower energy turnover during force development found for fast-twitch skeletal muscle of hypothyroid rats. Moreover, the increase in twitch force by hypothyroidism cannot be explained by a change in myosin P-light chain phosphorylation. Isometric twitch tension potentiation after a 2 s tetanus and during low-frequency repetitive stimulation was reduced (up to -60%) in muscles of hypothyroid rats, which may well be related to the lower extent of P-light chain phosphorylation in hypothyroids. | lld:pubmed |
| pubmed-article:2960952 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2960952 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2960952 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2960952 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2960952 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2960952 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2960952 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2960952 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2960952 | pubmed:issn | 0031-6768 | lld:pubmed |
| pubmed-article:2960952 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:2960952 | pubmed:author | pubmed-author:LeijendekkerW... | lld:pubmed |
| pubmed-article:2960952 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2960952 | pubmed:volume | 410 | lld:pubmed |
| pubmed-article:2960952 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2960952 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2960952 | pubmed:pagination | 48-54 | lld:pubmed |
| pubmed-article:2960952 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:2960952 | pubmed:meshHeading | pubmed-meshheading:2960952-... | lld:pubmed |
| pubmed-article:2960952 | pubmed:meshHeading | pubmed-meshheading:2960952-... | lld:pubmed |
| pubmed-article:2960952 | pubmed:meshHeading | pubmed-meshheading:2960952-... | lld:pubmed |
| pubmed-article:2960952 | pubmed:meshHeading | pubmed-meshheading:2960952-... | lld:pubmed |
| pubmed-article:2960952 | pubmed:meshHeading | pubmed-meshheading:2960952-... | lld:pubmed |
| pubmed-article:2960952 | pubmed:meshHeading | pubmed-meshheading:2960952-... | lld:pubmed |
| pubmed-article:2960952 | pubmed:meshHeading | pubmed-meshheading:2960952-... | lld:pubmed |
| pubmed-article:2960952 | pubmed:meshHeading | pubmed-meshheading:2960952-... | lld:pubmed |
| pubmed-article:2960952 | pubmed:meshHeading | pubmed-meshheading:2960952-... | lld:pubmed |
| pubmed-article:2960952 | pubmed:meshHeading | pubmed-meshheading:2960952-... | lld:pubmed |
| pubmed-article:2960952 | pubmed:meshHeading | pubmed-meshheading:2960952-... | lld:pubmed |
| pubmed-article:2960952 | pubmed:meshHeading | pubmed-meshheading:2960952-... | lld:pubmed |
| pubmed-article:2960952 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2960952 | pubmed:articleTitle | Structural and functional aspects of the actomyosin complex from fast-twitch muscle of euthyroid and hypothyroid rats. | lld:pubmed |
| pubmed-article:2960952 | pubmed:affiliation | Laboratory for Physiology, Free University, Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:2960952 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2960952 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2960952 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
