| pubmed-article:2960825 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2960825 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2960825 | lifeskim:mentions | umls-concept:C0927232 | lld:lifeskim |
| pubmed-article:2960825 | lifeskim:mentions | umls-concept:C0007412 | lld:lifeskim |
| pubmed-article:2960825 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2960825 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:2960825 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:2960825 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2960825 | pubmed:dateCreated | 1988-1-19 | lld:pubmed |
| pubmed-article:2960825 | pubmed:abstractText | This study extends our previous findings, which indicate that depletion of CNS catecholamines has a marked inhibitory effect on humoral immune responsiveness. These data show that depletion of CNS catecholamines by injection of 6-hydroxydopamine (6-OHDA) into the cisterna magna in conjunction with immunization enhances the activity of a population of splenic T-suppressor cells as evidenced by the transfer of these cells to normal recipients. Increased suppressor cell activity does not result solely from 6-OHDA treatment, but rather requires concomitant immunization. Further characterization shows that these suppressor cells are not antigen specific. Hypophysectomy abrogates the effects of 6-OHDA injection suggesting that catecholamine depletion modulates immune function via the release of pituitary hormones. Thus, depletion of CNS catecholamines impairs immune responsiveness by inducing enhanced T-suppressor cell activity, providing additional evidence of the involvement of the CNS in regulation of immune responsiveness. | lld:pubmed |
| pubmed-article:2960825 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2960825 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2960825 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2960825 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2960825 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2960825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2960825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2960825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2960825 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2960825 | pubmed:issn | 0360-4012 | lld:pubmed |
| pubmed-article:2960825 | pubmed:author | pubmed-author:BrooksW HWH | lld:pubmed |
| pubmed-article:2960825 | pubmed:author | pubmed-author:RoszmanT LTL | lld:pubmed |
| pubmed-article:2960825 | pubmed:author | pubmed-author:CrossR JRJ | lld:pubmed |
| pubmed-article:2960825 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2960825 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:2960825 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2960825 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2960825 | pubmed:pagination | 75-81 | lld:pubmed |
| pubmed-article:2960825 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2960825 | pubmed:meshHeading | pubmed-meshheading:2960825-... | lld:pubmed |
| pubmed-article:2960825 | pubmed:meshHeading | pubmed-meshheading:2960825-... | lld:pubmed |
| pubmed-article:2960825 | pubmed:meshHeading | pubmed-meshheading:2960825-... | lld:pubmed |
| pubmed-article:2960825 | pubmed:meshHeading | pubmed-meshheading:2960825-... | lld:pubmed |
| pubmed-article:2960825 | pubmed:meshHeading | pubmed-meshheading:2960825-... | lld:pubmed |
| pubmed-article:2960825 | pubmed:meshHeading | pubmed-meshheading:2960825-... | lld:pubmed |
| pubmed-article:2960825 | pubmed:meshHeading | pubmed-meshheading:2960825-... | lld:pubmed |
| pubmed-article:2960825 | pubmed:meshHeading | pubmed-meshheading:2960825-... | lld:pubmed |
| pubmed-article:2960825 | pubmed:meshHeading | pubmed-meshheading:2960825-... | lld:pubmed |
| pubmed-article:2960825 | pubmed:meshHeading | pubmed-meshheading:2960825-... | lld:pubmed |
| pubmed-article:2960825 | pubmed:meshHeading | pubmed-meshheading:2960825-... | lld:pubmed |
| pubmed-article:2960825 | pubmed:meshHeading | pubmed-meshheading:2960825-... | lld:pubmed |
| pubmed-article:2960825 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2960825 | pubmed:articleTitle | Modulation of T-suppressor cell activity by central nervous system catecholamine depletion. | lld:pubmed |
| pubmed-article:2960825 | pubmed:affiliation | Department of Microbiology and Immunology, University of Kentucky Medical Center, Lexington 40536-0084. | lld:pubmed |
| pubmed-article:2960825 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2960825 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
