| pubmed-article:2952584 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2952584 | lifeskim:mentions | umls-concept:C0038856 | lld:lifeskim |
| pubmed-article:2952584 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2952584 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2952584 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2952584 | pubmed:dateCreated | 1987-6-9 | lld:pubmed |
| pubmed-article:2952584 | pubmed:abstractText | The suppression of contact hypersensitivity (CHS) after a single exposure to ultraviolet (UV) radiation provides an excellent model system with which to study both the activation and the mode of action of suppressor T cells. Suppression of CHS after UV radiation is mediated by hapten-specific suppressor T cells (UVTs). These cells have a broad range of activity: CHS and antibody production in vivo and the generation of cytolytic T lymphocytes (CTL) and T-cell proliferative responses in vitro are suppressed by UVTs. The present study is concerned with determining the target of UVTs. The UVTs could suppress the response to hapten-modified T-dependent antigens, such as trinitrophenyl (TNP)-modified sheep erythrocytes (TNP-SRBC) or TNP-conjugated bovine serum albumin (TNP-BSA), but had no suppressive effect on the response to a T-independent antigen, TNP-conjugated lipopolysaccharide (TNP-LPS). The UVTs also suppressed the generation of interleukin-2 (IL-2) in vitro. The suppression of CTL generation in vitro and CHS in vivo could be overcome by the addition of exogenous IL-2. These data suggest that UVTs suppress the immune response by affecting T-helper cell function. | lld:pubmed |
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| pubmed-article:2952584 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2952584 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2952584 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2952584 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2952584 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2952584 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:2952584 | pubmed:author | pubmed-author:UllrichS ESE | lld:pubmed |
| pubmed-article:2952584 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2952584 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:2952584 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2952584 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2952584 | pubmed:pagination | 353-60 | lld:pubmed |
| pubmed-article:2952584 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2952584 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2952584 | pubmed:articleTitle | The effect of ultraviolet radiation-induced suppressor cells on T-cell activity. | lld:pubmed |
| pubmed-article:2952584 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2952584 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2952584 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2952584 | lld:pubmed |
