| pubmed-article:2947967 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2947967 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2947967 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2947967 | lifeskim:mentions | umls-concept:C0027707 | lld:lifeskim |
| pubmed-article:2947967 | lifeskim:mentions | umls-concept:C0004368 | lld:lifeskim |
| pubmed-article:2947967 | lifeskim:mentions | umls-concept:C0205161 | lld:lifeskim |
| pubmed-article:2947967 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2947967 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2947967 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2947967 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2947967 | pubmed:dateCreated | 1987-1-29 | lld:pubmed |
| pubmed-article:2947967 | pubmed:abstractText | We have used the murine model of spontaneous autoimmune interstitial nephritis in kdkd mice to examine the importance of abnormal immunoregulation in the expression of disease. T cells from naive congenic CBA/Ca mice suppress both histologic renal injury in the kdkd strain as well as the DTH reactivity to CBA/Ca renal tubular antigens mediated by lymphocytes from nephritic kdkd mice. These antigen-specific suppressor T cells are Lyt-2+, L3T4+, I-Jk+, genetically dominant and I-Jk restricted. Unfractionated spleen cells from young, prenephritic kdkd mice also demonstrate such suppressor function. Shortly preceding disease onset, however, net suppression is functionally bypassed by emergent contrasuppressor T cells. These regulatory cells are also Lyt-2+ and I-Jk+, and adhere both to the Vicia Villosa lectin and CBA/Ca TBM. By admixing these contrasuppressor cells with spleen cells from non-disease-prone CBA/Ca mice we were able to demonstrate the presence of DTH-reactive and nephritogenic effector cells in the latter population. Such nephritogenic effector cells could also be simply demonstrated after depletion of the suppressor cells with anti-I-Jk mAbs and complement. These findings support a role for contrasuppressor cells in the abrogation of tolerance to parenchymal self-antigens. | lld:pubmed |
| pubmed-article:2947967 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2947967 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2947967 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2947967 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2947967 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2947967 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2947967 | pubmed:author | pubmed-author:KellyC JCJ | lld:pubmed |
| pubmed-article:2947967 | pubmed:author | pubmed-author:NeilsonE GEG | lld:pubmed |
| pubmed-article:2947967 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2947967 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2947967 | pubmed:volume | 165 | lld:pubmed |
| pubmed-article:2947967 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2947967 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2947967 | pubmed:pagination | 107-23 | lld:pubmed |
| pubmed-article:2947967 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:meshHeading | pubmed-meshheading:2947967-... | lld:pubmed |
| pubmed-article:2947967 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2947967 | pubmed:articleTitle | Contrasuppression in autoimmunity. Abnormal contrasuppression facilitates expression of nephritogenic effector T cells and interstitial nephritis in kdkd mice. | lld:pubmed |
| pubmed-article:2947967 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2947967 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2947967 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2947967 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2947967 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2947967 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2947967 | lld:pubmed |
