| pubmed-article:2938859 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2938859 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:2938859 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:2938859 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:2938859 | lifeskim:mentions | umls-concept:C0034819 | lld:lifeskim |
| pubmed-article:2938859 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:2938859 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:2938859 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2938859 | pubmed:dateCreated | 1986-6-18 | lld:pubmed |
| pubmed-article:2938859 | pubmed:abstractText | The effects of interleukin-2 (IL-2) on the expression of IL-2 receptors by cloned cytolytic and helper T lymphocytes were studied using three anti-IL-2 receptor antibodies. IL-2 enhanced the expression of IL-2 receptors on all clones tested. A steep dose-response curve was observed with no measurable effect seen below 2 units/ml and maximal IL-2 receptor expression with greater than 5 units/ml. IL-2 receptor expression peaked 24-48 hr after the addition of IL-2. The subsequent decrease in IL-2 receptor expression correlated with a decrease in the levels of IL-2 remaining in the culture supernatants of cytolytic T lymphocyte cells. Removing residual IL-2 from cultures resulted in the rapid return of IL-2 receptor expression to unstimulated levels. The daily addition of low levels of IL-2 to cultures resulted in the prolonged expression of high levels of IL-2 receptors by non-IL-2-producing cloned cytolytic T cells. Cloned helper T cells which make IL-2 showed the initial increase in IL-2 receptor levels, but the daily addition of IL-2 did not prolong IL-2 receptor expression in these cells. These data suggest that IL-2 receptors on those cells which do not make IL-2 are regulated differently from receptors on cells which themselves make IL-2. | lld:pubmed |
| pubmed-article:2938859 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2938859 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2938859 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2938859 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2938859 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2938859 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2938859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2938859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2938859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2938859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2938859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2938859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2938859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2938859 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2938859 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2938859 | pubmed:issn | 0090-1229 | lld:pubmed |
| pubmed-article:2938859 | pubmed:author | pubmed-author:FitchF WFW | lld:pubmed |
| pubmed-article:2938859 | pubmed:author | pubmed-author:KimD KDK | lld:pubmed |
| pubmed-article:2938859 | pubmed:author | pubmed-author:LanckiD WDW | lld:pubmed |
| pubmed-article:2938859 | pubmed:author | pubmed-author:HavranW LWL | lld:pubmed |
| pubmed-article:2938859 | pubmed:author | pubmed-author:MoldwinR LRL | lld:pubmed |
| pubmed-article:2938859 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2938859 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:2938859 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2938859 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2938859 | pubmed:pagination | 368-78 | lld:pubmed |
| pubmed-article:2938859 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2938859 | pubmed:meshHeading | pubmed-meshheading:2938859-... | lld:pubmed |
| pubmed-article:2938859 | pubmed:meshHeading | pubmed-meshheading:2938859-... | lld:pubmed |
| pubmed-article:2938859 | pubmed:meshHeading | pubmed-meshheading:2938859-... | lld:pubmed |
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| pubmed-article:2938859 | pubmed:meshHeading | pubmed-meshheading:2938859-... | lld:pubmed |
| pubmed-article:2938859 | pubmed:meshHeading | pubmed-meshheading:2938859-... | lld:pubmed |
| pubmed-article:2938859 | pubmed:meshHeading | pubmed-meshheading:2938859-... | lld:pubmed |
| pubmed-article:2938859 | pubmed:meshHeading | pubmed-meshheading:2938859-... | lld:pubmed |
| pubmed-article:2938859 | pubmed:meshHeading | pubmed-meshheading:2938859-... | lld:pubmed |
| pubmed-article:2938859 | pubmed:meshHeading | pubmed-meshheading:2938859-... | lld:pubmed |
| pubmed-article:2938859 | pubmed:meshHeading | pubmed-meshheading:2938859-... | lld:pubmed |
| pubmed-article:2938859 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2938859 | pubmed:articleTitle | Interleukin-2 differentially regulates IL-2 receptors on murine cloned cytolytic and helper T cells. | lld:pubmed |
| pubmed-article:2938859 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2938859 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
