| pubmed-article:2919825 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2919825 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2919825 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:2919825 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:2919825 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:2919825 | lifeskim:mentions | umls-concept:C0678559 | lld:lifeskim |
| pubmed-article:2919825 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2919825 | pubmed:dateCreated | 1989-3-29 | lld:pubmed |
| pubmed-article:2919825 | pubmed:abstractText | We evaluated the deformability of bovine platelets and contrasted the effects of pharmacologic and thermal perturbations on cytoskeletal structure of human and bovine platelets. Platelets were aspirated into micropipettes (0.7 to 0.8 micron in diameter) by stepwise increments in tension. The resulting lengths of the cell extensions were recorded. The cell extensions aspirated from bovine platelets were shorter than the extensions drawn from human platelets. Disassembly of the circumferential microtubule coil allowed human platelets to pass through the pipette, but the same treatments only slightly increased the deformability of bovine platelets. Alteration of the actin filament cytoskeleton caused increased mechanical fragility of human platelets. In contrast, even the combined use of microtubule and actin filament-disrupting agents only modestly increased the deformability of bovine platelets and did not cause premature fragmentation of the cells. Unusual cytoskeletal structure, absence of an open canalicular system, and disparity in granule size may all contribute to the variance in deformability between the platelets of the 2 species. Reduced cell deformability may impair bovine platelet surface interactions by diminishing the ease of cell spreading and formation of areas of contact between the platelet and other cell surfaces. | lld:pubmed |
| pubmed-article:2919825 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2919825 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2919825 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2919825 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2919825 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2919825 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2919825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2919825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2919825 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2919825 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2919825 | pubmed:issn | 0002-9645 | lld:pubmed |
| pubmed-article:2919825 | pubmed:author | pubmed-author:WhiteJ GJG | lld:pubmed |
| pubmed-article:2919825 | pubmed:author | pubmed-author:WeissD JDJ | lld:pubmed |
| pubmed-article:2919825 | pubmed:author | pubmed-author:SmithC MCM2nd | lld:pubmed |
| pubmed-article:2919825 | pubmed:author | pubmed-author:BurrisS MSM | lld:pubmed |
| pubmed-article:2919825 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2919825 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:2919825 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2919825 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2919825 | pubmed:pagination | 34-8 | lld:pubmed |
| pubmed-article:2919825 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:2919825 | pubmed:meshHeading | pubmed-meshheading:2919825-... | lld:pubmed |
| pubmed-article:2919825 | pubmed:meshHeading | pubmed-meshheading:2919825-... | lld:pubmed |
| pubmed-article:2919825 | pubmed:meshHeading | pubmed-meshheading:2919825-... | lld:pubmed |
| pubmed-article:2919825 | pubmed:meshHeading | pubmed-meshheading:2919825-... | lld:pubmed |
| pubmed-article:2919825 | pubmed:meshHeading | pubmed-meshheading:2919825-... | lld:pubmed |
| pubmed-article:2919825 | pubmed:meshHeading | pubmed-meshheading:2919825-... | lld:pubmed |
| pubmed-article:2919825 | pubmed:meshHeading | pubmed-meshheading:2919825-... | lld:pubmed |
| pubmed-article:2919825 | pubmed:meshHeading | pubmed-meshheading:2919825-... | lld:pubmed |
| pubmed-article:2919825 | pubmed:meshHeading | pubmed-meshheading:2919825-... | lld:pubmed |
| pubmed-article:2919825 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2919825 | pubmed:articleTitle | Comparison of bovine and human platelet deformability, using micropipette elastimetry. | lld:pubmed |
| pubmed-article:2919825 | pubmed:affiliation | Department of Pediatrics, University of Minnesota Health Sciences Center, Minneapolis 55455. | lld:pubmed |
| pubmed-article:2919825 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2919825 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2919825 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2919825 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2919825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2919825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2919825 | lld:pubmed |
