| pubmed-article:2919089 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2919089 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2919089 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2919089 | lifeskim:mentions | umls-concept:C0104808 | lld:lifeskim |
| pubmed-article:2919089 | lifeskim:mentions | umls-concept:C0052854 | lld:lifeskim |
| pubmed-article:2919089 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2919089 | pubmed:dateCreated | 1989-4-6 | lld:pubmed |
| pubmed-article:2919089 | pubmed:abstractText | Subcutaneous (s.c.) administration of azepexole (BHT 933) at doses between 4 and 40 mg/kg produced dose-dependent antinociceptive effects in mice as assessed by tail-immersion, tail-pinch and acetic acid writhing tests. The ED16s were 5.6 +/- 0.4, 6.7 +/- 1.2 and 2.96 +/- 0.2 mg/kg respectively. Similarly, morphine produced analgesia in the same tests with ED16s of 0.87 +/- 0.03, 0.47 +/- 0.1 and 0.45 +/- 0.01 mg/kg respectively. In all instances naloxone (0.1 mg/kg s.c.) shifted the dose-response curves to morphine to the right in a parallel manner. Naloxone (0.1 and 1 mg/kg s.c.) partially antagonized the effect of azepexole in the tail-immersion and tail-pinch tests but significantly decreased the slope of the dose-response curve suggesting that a competitive interaction at the level of the opioid receptors did not occur. Naloxone had no effect on the antinociceptive action of azepexole in the acetic acid writhing test. | lld:pubmed |
| pubmed-article:2919089 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2919089 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2919089 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2919089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2919089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2919089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2919089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2919089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2919089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2919089 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2919089 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2919089 | pubmed:issn | 0304-3959 | lld:pubmed |
| pubmed-article:2919089 | pubmed:author | pubmed-author:TurndorfHH | lld:pubmed |
| pubmed-article:2919089 | pubmed:author | pubmed-author:PuigM MMM | lld:pubmed |
| pubmed-article:2919089 | pubmed:author | pubmed-author:BansinathMM | lld:pubmed |
| pubmed-article:2919089 | pubmed:author | pubmed-author:VargasM LML | lld:pubmed |
| pubmed-article:2919089 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2919089 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:2919089 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2919089 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2919089 | pubmed:pagination | 117-23 | lld:pubmed |
| pubmed-article:2919089 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2919089 | pubmed:meshHeading | pubmed-meshheading:2919089-... | lld:pubmed |
| pubmed-article:2919089 | pubmed:meshHeading | pubmed-meshheading:2919089-... | lld:pubmed |
| pubmed-article:2919089 | pubmed:meshHeading | pubmed-meshheading:2919089-... | lld:pubmed |
| pubmed-article:2919089 | pubmed:meshHeading | pubmed-meshheading:2919089-... | lld:pubmed |
| pubmed-article:2919089 | pubmed:meshHeading | pubmed-meshheading:2919089-... | lld:pubmed |
| pubmed-article:2919089 | pubmed:meshHeading | pubmed-meshheading:2919089-... | lld:pubmed |
| pubmed-article:2919089 | pubmed:meshHeading | pubmed-meshheading:2919089-... | lld:pubmed |
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| pubmed-article:2919089 | pubmed:meshHeading | pubmed-meshheading:2919089-... | lld:pubmed |
| pubmed-article:2919089 | pubmed:meshHeading | pubmed-meshheading:2919089-... | lld:pubmed |
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| pubmed-article:2919089 | pubmed:meshHeading | pubmed-meshheading:2919089-... | lld:pubmed |
| pubmed-article:2919089 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2919089 | pubmed:articleTitle | Antinociceptive effects of azepexole (BHT 933) in mice. | lld:pubmed |
| pubmed-article:2919089 | pubmed:affiliation | Department of Pharmacology, Murcia University School of Medicine, Spain. | lld:pubmed |
| pubmed-article:2919089 | pubmed:publicationType | Journal Article | lld:pubmed |
