Linked Life Data

290992

Source:http://linkedlifedata.com/resource/pubmed/id/290992

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pubmed-article:290992pubmed:abstractTextThe pentapeptide Phe-Leu-Glu-Glu-Leu, tritiated at the gamma carbon of each Glu residue, has been synthesized. In a system using microsomal preparations derived from rat liver, vitamin K-dependent tritium release from the L-Glu residues of this substrate can occur without the concurrent gamma-carboxylation of Glu. This tritium release reaction, which indicates cleavage of the gamma C-H bond, although easily uncoupled from CO2-dependent gamma C carboxylation, does require the reduced (hydroquinone) form of vitamin K and oxygen. The data argue against a concerted mechanism for the cleavage of the gamma C-H bond and carboxylation and against a mechanism in which the vitamin functions solely to transfer or activate CO2. Although the tritium release is related clearly to the oxidation of vitamin KH2, it is not yet established how the subsequent carboxylation proceeds. However, two carboxylation mechanisms compatible with the results are discussed.lld:pubmed
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pubmed-article:290992pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:290992pubmed:articleTitleVitamin K-dependent gamma-carbon-hydrogen bond cleavage and nonmandatory concurrent carboxylation of peptide-bound glutamic acid residues.lld:pubmed
pubmed-article:290992pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:290992pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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