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pubmed-article:2904419pubmed:abstractTextA high incidence of luteal phase defect (LPD) has been reported using subcutaneous pulsatile gonadotropin-releasing hormone for induction of ovulation. We reviewed all patients treated with the combination of subcutaneous pulsatile gonadotropin-releasing hormone during the follicular phase and human chorionic gonadotropin during the luteal phase (GnRH-hCG) who underwent endometrial biopsy during a treatment cycle. All of these patients had biopsy-proven LPD which persisted despite traditional therapy with progesterone vaginal suppositories and/or clomiphene citrate. The mean number of biopsies out of phase per patient prior to GnRH-hCG treatment was 2.8 +/- 0.2 (+/- SEM). When treated with GnRH-hCG, 15/16 patients (94%) showed a normal endometrial biopsy. The probability of this result occurring by chance alone allowing for a 50% treatment independent correction rate is less than .001. These results show that the combination of subcutaneous pulsatile gonadotropin-releasing hormone and luteal-phase human chorionic gonadotropin can result in normal endometrial maturation in a high percentage of cycles when administered as described. It appears to be an effective alternative to traditional treatment modalities for luteal phase defect should one be needed.lld:pubmed
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pubmed-article:2904419pubmed:authorpubmed-author:TagatzG EGElld:pubmed
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pubmed-article:2904419pubmed:pagination329-33lld:pubmed
pubmed-article:2904419pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:2904419pubmed:articleTitleEndometrial biopsies during treatment with subcutaneous pulsatile gonadotropin-releasing hormone and luteal-phase human chorionic gonadotropin.lld:pubmed
pubmed-article:2904419pubmed:affiliationUniversity of Minnesota Medical School, Department of Obstetrics and Gynecology, Minneapolis.lld:pubmed
pubmed-article:2904419pubmed:publicationTypeJournal Articlelld:pubmed