pubmed-article:2904419 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:2904419 | lifeskim:mentions | umls-concept:C0443315 | lld:lifeskim |
pubmed-article:2904419 | lifeskim:mentions | umls-concept:C1510477 | lld:lifeskim |
pubmed-article:2904419 | lifeskim:mentions | umls-concept:C0023610 | lld:lifeskim |
pubmed-article:2904419 | lifeskim:mentions | umls-concept:C1141639 | lld:lifeskim |
pubmed-article:2904419 | lifeskim:mentions | umls-concept:C2709058 | lld:lifeskim |
pubmed-article:2904419 | pubmed:issue | 5 | lld:pubmed |
pubmed-article:2904419 | pubmed:dateCreated | 1989-1-18 | lld:pubmed |
pubmed-article:2904419 | pubmed:abstractText | A high incidence of luteal phase defect (LPD) has been reported using subcutaneous pulsatile gonadotropin-releasing hormone for induction of ovulation. We reviewed all patients treated with the combination of subcutaneous pulsatile gonadotropin-releasing hormone during the follicular phase and human chorionic gonadotropin during the luteal phase (GnRH-hCG) who underwent endometrial biopsy during a treatment cycle. All of these patients had biopsy-proven LPD which persisted despite traditional therapy with progesterone vaginal suppositories and/or clomiphene citrate. The mean number of biopsies out of phase per patient prior to GnRH-hCG treatment was 2.8 +/- 0.2 (+/- SEM). When treated with GnRH-hCG, 15/16 patients (94%) showed a normal endometrial biopsy. The probability of this result occurring by chance alone allowing for a 50% treatment independent correction rate is less than .001. These results show that the combination of subcutaneous pulsatile gonadotropin-releasing hormone and luteal-phase human chorionic gonadotropin can result in normal endometrial maturation in a high percentage of cycles when administered as described. It appears to be an effective alternative to traditional treatment modalities for luteal phase defect should one be needed. | lld:pubmed |
pubmed-article:2904419 | pubmed:language | eng | lld:pubmed |
pubmed-article:2904419 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2904419 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:2904419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2904419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2904419 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:2904419 | pubmed:issn | 0020-725X | lld:pubmed |
pubmed-article:2904419 | pubmed:author | pubmed-author:TagatzG EGE | lld:pubmed |
pubmed-article:2904419 | pubmed:author | pubmed-author:NagelT CTC | lld:pubmed |
pubmed-article:2904419 | pubmed:author | pubmed-author:CampbellB FBF | lld:pubmed |
pubmed-article:2904419 | pubmed:author | pubmed-author:PhippsW RWR | lld:pubmed |
pubmed-article:2904419 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:2904419 | pubmed:volume | 33 | lld:pubmed |
pubmed-article:2904419 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:2904419 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:2904419 | pubmed:pagination | 329-33 | lld:pubmed |
pubmed-article:2904419 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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pubmed-article:2904419 | pubmed:articleTitle | Endometrial biopsies during treatment with subcutaneous pulsatile gonadotropin-releasing hormone and luteal-phase human chorionic gonadotropin. | lld:pubmed |
pubmed-article:2904419 | pubmed:affiliation | University of Minnesota Medical School, Department of Obstetrics and Gynecology, Minneapolis. | lld:pubmed |
pubmed-article:2904419 | pubmed:publicationType | Journal Article | lld:pubmed |