| pubmed-article:2893840 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2893840 | lifeskim:mentions | umls-concept:C0009368 | lld:lifeskim |
| pubmed-article:2893840 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:2893840 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:2893840 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:2893840 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:2893840 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:2893840 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2893840 | pubmed:dateCreated | 1988-4-4 | lld:pubmed |
| pubmed-article:2893840 | pubmed:abstractText | The motor responses of the caecum and colon to stimulation of alpha 2-adrenoceptors by xylazine and detomidine at the recommended dose levels of 0.6 and 0.1 mg/kg were investigated in three ponies. The motor changes of the left ventral colon induced by continuous intra-arterial infusion of a prostaglandin (PGF2 alpha) were used to assess the relative inhibitory effects of xylazine and detomidine in a colic model. The administration of alpha 2-agonists inhibited the spiking activity on the whole of the large intestine for 20-30 min (xylazine) or 2-3 h (detomidine). However, the detomidine-induced inhibition was preceded by a short period of increased smooth muscle basal tone as indicated by strain-gauge force transducer measurements. This pattern of activity was neither reversed nor prevented by the administration of tolazoline (10 micrograms/kg/min) intra-arterially. In contrast, inhibition of the colonic phasic and tonic motor activity by alpha 2-adrenoceptor stimulation was reversed competitively by tolazoline. The intra-arterial infusion of prostaglandin F2 alpha (10 micrograms/kg/min) induced prolonged and sustained spiking activity that might be related to signs of mild colic. Detomidine, and to a lesser extent xylazine, relaxed the whole of the large intestine and this was accompanied by alleviation of the signs of visceral pain. | lld:pubmed |
| pubmed-article:2893840 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2893840 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2893840 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2893840 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2893840 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2893840 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2893840 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2893840 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2893840 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2893840 | pubmed:issn | 0140-7783 | lld:pubmed |
| pubmed-article:2893840 | pubmed:author | pubmed-author:RuckebuschYY | lld:pubmed |
| pubmed-article:2893840 | pubmed:author | pubmed-author:RogerTT | lld:pubmed |
| pubmed-article:2893840 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2893840 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:2893840 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2893840 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2893840 | pubmed:pagination | 310-8 | lld:pubmed |
| pubmed-article:2893840 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2893840 | pubmed:meshHeading | pubmed-meshheading:2893840-... | lld:pubmed |
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| pubmed-article:2893840 | pubmed:meshHeading | pubmed-meshheading:2893840-... | lld:pubmed |
| pubmed-article:2893840 | pubmed:meshHeading | pubmed-meshheading:2893840-... | lld:pubmed |
| pubmed-article:2893840 | pubmed:meshHeading | pubmed-meshheading:2893840-... | lld:pubmed |
| pubmed-article:2893840 | pubmed:meshHeading | pubmed-meshheading:2893840-... | lld:pubmed |
| pubmed-article:2893840 | pubmed:meshHeading | pubmed-meshheading:2893840-... | lld:pubmed |
| pubmed-article:2893840 | pubmed:meshHeading | pubmed-meshheading:2893840-... | lld:pubmed |
| pubmed-article:2893840 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2893840 | pubmed:articleTitle | Colonic alpha 2-adrenoceptor-mediated responses in the pony. | lld:pubmed |
| pubmed-article:2893840 | pubmed:affiliation | Department of Physiology, National Veterinary School, Toulouse, France. | lld:pubmed |
| pubmed-article:2893840 | pubmed:publicationType | Journal Article | lld:pubmed |
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