| pubmed-article:2887587 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2887587 | lifeskim:mentions | umls-concept:C0023493 | lld:lifeskim |
| pubmed-article:2887587 | lifeskim:mentions | umls-concept:C1708431 | lld:lifeskim |
| pubmed-article:2887587 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2887587 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2887587 | pubmed:dateCreated | 1987-10-7 | lld:pubmed |
| pubmed-article:2887587 | pubmed:abstractText | The adult T cell leukemia (ATL) is a T cell neoplasm etiologically associated with human T lymphotropic virus type I (HTLV-I) infection. ATL cells often abnormally express interleukin 2 (IL-2) receptors, and ATL patients may show clinical evidence of hypercalcemia, osteolytic bone lesions, or increased bone turnover. Whereas interleukin 1 (IL-1) is not generally recognized as a product of T cells, this cytokine is capable of both altering IL-2 receptor expression and activating osteoclasts. Thus, we investigated the possibility that primary ATL leukemic T cells and HTLV-I-infected long-term ATL cell lines produce IL-1. S1 nuclease protection assays demonstrated that primary leukemic ATL cells from five out of six patients, as well as one patient with T4+ chronic lymphocytic leukemia, contained considerable quantities of IL-1 beta messenger RNA (mRNA) and small amounts of IL-1 alpha mRNA. These primary leukemic T cells also released biologically active IL-1 protein as evaluated in the murine thymocyte comitogenesis bioassay. In contrast to primary tumor cells, four out of six long-term ATL cell lines produced variable amounts of IL-1 alpha mRNA in the absence of detectable IL-1 beta mRNA as measured by S1 nuclease protection. These data demonstrate that IL-1 gene (especially IL-1 beta) expression occurs in many primary HTLV-I-infected leukemic T cells raising the possibility that this mediator may play a role in the pathological changes associated with this leukemia. Also, these studies show that the pattern of IL-1 alpha and IL-1 beta gene expression differs between primary ATL tumor cells and long-term cultured ATL cell lines, indicating an interesting biological difference in these two HTLV-I-infected cell populations. | lld:pubmed |
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| pubmed-article:2887587 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2887587 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2887587 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2887587 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2887587 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2887587 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:2887587 | pubmed:author | pubmed-author:HattoriTT | lld:pubmed |
| pubmed-article:2887587 | pubmed:author | pubmed-author:MatsuokaMM | lld:pubmed |
| pubmed-article:2887587 | pubmed:author | pubmed-author:TakatsukiKK | lld:pubmed |
| pubmed-article:2887587 | pubmed:author | pubmed-author:GreeneW CWC | lld:pubmed |
| pubmed-article:2887587 | pubmed:author | pubmed-author:WangQQ | lld:pubmed |
| pubmed-article:2887587 | pubmed:author | pubmed-author:GublerUU | lld:pubmed |
| pubmed-article:2887587 | pubmed:author | pubmed-author:EhmsHH | lld:pubmed |
| pubmed-article:2887587 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2887587 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:2887587 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2887587 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2887587 | pubmed:pagination | 911-6 | lld:pubmed |
| pubmed-article:2887587 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2887587 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2887587 | pubmed:articleTitle | Interleukin 1 gene expression in adult T cell leukemia. | lld:pubmed |
| pubmed-article:2887587 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2887587 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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