| pubmed-article:2851861 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2851861 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2851861 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:2851861 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:2851861 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:2851861 | lifeskim:mentions | umls-concept:C0205923 | lld:lifeskim |
| pubmed-article:2851861 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2851861 | pubmed:dateCreated | 1989-3-17 | lld:pubmed |
| pubmed-article:2851861 | pubmed:abstractText | 1. Benzodiazepine receptors have been characterized in human brain mainly using [3H]-Ro 15-1788 and [3H]-flunitrazepam. Both ligands present a very high affinity for the receptor sites (Kd values of 0.56 and 1.53 nM respectively). 2. GABA enhanced the affinity of [3H]-flunitrazepam and [3H]-diazepam, but not that of [3H]-Ro 15-1788 and [3H]-methyl-beta-carboline 3-carboxylate for their specific binding sites as well in cerebral as in cerebellar human cortex. 3. Subcellular distribution of the benzodiazepine receptors revealed a main synaptosomal localization in human cerebral cortex, cerebellum and striatum. 4. Solubilized benzodiazepine receptors were obtained using 0.5% sodium deoxycholate and were characterized with [3H]-Ro 15-1788. The solubilized receptors are still coupled to GABA receptors since the [3H]-flunitrazepam specific binding was enhanced in the presence of micromolar concentrations of GABA. | lld:pubmed |
| pubmed-article:2851861 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2851861 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2851861 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2851861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2851861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2851861 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2851861 | pubmed:issn | 0278-5846 | lld:pubmed |
| pubmed-article:2851861 | pubmed:author | pubmed-author:AckermannDD | lld:pubmed |
| pubmed-article:2851861 | pubmed:author | pubmed-author:OctaveJ NJN | lld:pubmed |
| pubmed-article:2851861 | pubmed:author | pubmed-author:LaterreCC | lld:pubmed |
| pubmed-article:2851861 | pubmed:author | pubmed-author:MaloteauxJ... | lld:pubmed |
| pubmed-article:2851861 | pubmed:author | pubmed-author:VanisbergM... | lld:pubmed |
| pubmed-article:2851861 | pubmed:author | pubmed-author:KollmannPP | lld:pubmed |
| pubmed-article:2851861 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2851861 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:2851861 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2851861 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2851861 | pubmed:pagination | 773-82 | lld:pubmed |
| pubmed-article:2851861 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2851861 | pubmed:meshHeading | pubmed-meshheading:2851861-... | lld:pubmed |
| pubmed-article:2851861 | pubmed:meshHeading | pubmed-meshheading:2851861-... | lld:pubmed |
| pubmed-article:2851861 | pubmed:meshHeading | pubmed-meshheading:2851861-... | lld:pubmed |
| pubmed-article:2851861 | pubmed:meshHeading | pubmed-meshheading:2851861-... | lld:pubmed |
| pubmed-article:2851861 | pubmed:meshHeading | pubmed-meshheading:2851861-... | lld:pubmed |
| pubmed-article:2851861 | pubmed:meshHeading | pubmed-meshheading:2851861-... | lld:pubmed |
| pubmed-article:2851861 | pubmed:meshHeading | pubmed-meshheading:2851861-... | lld:pubmed |
| pubmed-article:2851861 | pubmed:meshHeading | pubmed-meshheading:2851861-... | lld:pubmed |
| pubmed-article:2851861 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2851861 | pubmed:articleTitle | Benzodiazepine receptors in human brain: characterization, subcellular localization and solubilization. | lld:pubmed |
| pubmed-article:2851861 | pubmed:affiliation | Université Catholique de Louvain, Laboratoire de Neurochimie Brussels, Belgium. | lld:pubmed |
| pubmed-article:2851861 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2851861 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
