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pubmed-article:2851003pubmed:abstractTextFerrocene-Haloperidol was synthesized by N-alkylation of 4-(4'-chlorophenyl)- 4-hydroxypiperidine with 1-ferrocenyl-4-chlor-butan-1-on. By heating the ferrocene-haloperidol with 103RuCl3 the 103Ru-labelled ruthenocene-haloperidol was obtained. This compound showed a high affinity for lung but not for brain in rats and mice. The decay of the 103Ru labelled compound results in the formation of the 103mRh labelled rhodocene-haloperidol, which is rapidly oxidized by air to the corresponding rhodocinium-haloperidol. This compound can be separated by extraction and TLC.lld:pubmed
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pubmed-article:2851003pubmed:dateRevised2009-6-4lld:pubmed
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pubmed-article:2851003pubmed:articleTitle[Ferrocene, ruthenocene and rhodocene analogs in haloperidol synthesis and organ distribution after labeling with 103Ru and 103mRh].lld:pubmed
pubmed-article:2851003pubmed:affiliationPharmazeutisches Institut, Freie Universität Berlin, Berlin-Dahlem, Deutschland.lld:pubmed
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