| pubmed-article:2846433 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2846433 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2846433 | lifeskim:mentions | umls-concept:C0005210 | lld:lifeskim |
| pubmed-article:2846433 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2846433 | lifeskim:mentions | umls-concept:C0683201 | lld:lifeskim |
| pubmed-article:2846433 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2846433 | pubmed:dateCreated | 1988-12-22 | lld:pubmed |
| pubmed-article:2846433 | pubmed:abstractText | Synthetic human beta endorphin shows a biphasic effect on the production of specific anti-herpes viral antibodies in vitro. At higher concentrations antibody production is reduced, at lower concentrations it is enhanced. In a proportion of donors whose cells do not produce specific antibody when cultured with antigen alone, the lower concentrations of beta endorphin allow antigen-driven specific antibody production to occur. Specific anti-herpes viral antibodies are also made by natural killer (NK) cell-depleted populations from the same non-producer donors. beta endorphin also exerts biphasic effects on NK, although the direction of the modulation is a mirror image of the effects on antibody production. This suggests that the immunomodulatory actions of beta endorphin on specific immune responses are mediated in part by effects on NK suppressor-inducer cells. | lld:pubmed |
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| pubmed-article:2846433 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2846433 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2846433 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2846433 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2846433 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2846433 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:2846433 | pubmed:author | pubmed-author:HobbsJ RJR | lld:pubmed |
| pubmed-article:2846433 | pubmed:author | pubmed-author:KnightR ARA | lld:pubmed |
| pubmed-article:2846433 | pubmed:author | pubmed-author:LightmanS LSL | lld:pubmed |
| pubmed-article:2846433 | pubmed:author | pubmed-author:WilliamsonS... | lld:pubmed |
| pubmed-article:2846433 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2846433 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:2846433 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2846433 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2846433 | pubmed:pagination | 47-51 | lld:pubmed |
| pubmed-article:2846433 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2846433 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2846433 | pubmed:articleTitle | Effects of beta endorphin on specific immune responses in man. | lld:pubmed |
| pubmed-article:2846433 | pubmed:affiliation | Dept. of Chemical Immunology, Charing Cross and Westminster Medical School, London, U.K. | lld:pubmed |
| pubmed-article:2846433 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2846433 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2846433 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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